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Diss Factsheets
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EC number: 252-743-7 | CAS number: 35835-94-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
For the source substance Ethyltriphenylphosphonium bromide, the read-across approach is based on the identity of the relevant dissociation product with the target substance: The source substance Ethyltriphenylphosphonium bromide is a salt dissociating readily in the bromide anion and the Ethyltriphenylphosphonium cation. The cation is identical for the target substance whereas the anion bromide is expected to enhance ecotoxicity compared to the target substance cation acetate.
For the source substance Methyltriphenylphosphonium chloride, the read-across approach is based on the similarity of the relevant dissociation product with the target substance: The source substance Methyltriphenylphosphonium chloride is a salt dissociating readily in the chloride anion and the Methyltriphenylphosphonium cation. The cation is similar for the target substance whereas the anion chloride is expected to have no influence on ecotoxicity compared to the target substance cation acetate.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
no additional information needed for the conclusion made from this read-across approach
3. ANALOGUE APPROACH JUSTIFICATION
For the target substance information on ecotoxicity is not yet available - testing is ongoing.
4. DATA MATRIX
To be provided when test results are available. - Sublethal observations / clinical signs:
Published information from Echa on aquatic toxicity for Ethyltriphenylphosphonium salts
ETHYLTRIPHENYLPHOSPHONIUM BROMIDE
https://echa.europa.eu/de/registration-dossier/-/registered-dossier/5487/6/2/2
fish 96h-EC50 ≥ 39.5mg/l
Ethyltriphenylfosfonium bromide
A 96 h study was conducted for CAS No.1530-32-1 on Danio rerio, at a test concentrations of 18 mg/L, 23.4 mg/L, 30.42 mg/L, 39.54 mg/L & 51.4 mg/L. The fishes were moving slowly as compared to control. No mortalities were found in the control aquaria.
daphnia 48h-EC50 = 24.6 mg/l
Prediction is done using QSAR Toolbox version 3.1
The effective concentration (EC50) value of ethyltriphenylfosfonium bromide in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of intoxication effect was estimated to be 24.623 mg/L.
algae 72h-ErC50 = 31mg/L
After 72 hours of exposure to Ethyltriphenylfosfonium bromide (CAS No. 1530-32-1) to various nominal test concentration, EC50 calculated from equation and graphically through probit analysis was found to be 30.9134 mg/L and 31.62 mg/L respectively.
-Iodide
no fish test
Methyltriphenylphosphonium chloride
https://echa.europa.eu/de/registration-dossier/-/registered-dossier/4850/6/2/4
fish 96h-EC50 ≥ 100mg/l
algae 72h-ErC50 = 2.7mg/l
daphnia 48h-EC50 = 1.1mg/l
- Conclusions:
- Published information from Echa homepage on aquatic toxicity of Ethyltriphenylphosphonium bromide and Methyltriphenylphosphonium chloride show, that fish is the least sensitive species in short term ecotoxicity tests compared to algae and daphnia.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ECOSAR v 2.0
2. MODEL (incl. version number)
ECOlogical Structure Activity Relationship (ECOSAR) software v2.0 for Microsoft Windows; U.S. Environmental Protection Agency; (October, 2017)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
P(CC(=O)(O))(c2ccccc2)(c3ccccc3)(c1ccccc1)CC
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
[Explain how the model fulfils the OECD principles for (Q)SAR model validation. Consider attaching the QMRF or providing a link]
- Defined endpoint:
Aquatic toxicity
- Unambiguous algorithm:
see attached justification
- Defined domain of applicability:
see attached justification
- Appropriate measures of goodness-of-fit and robustness and predictivity:
see attached justification
- Mechanistic interpretation:
see attached justification
5. APPLICABILITY DOMAIN
see attached justification
6. ADEQUACY OF THE RESULT
see attached justification - GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES:
P(CC(=O)(O))(c2ccccc2)(c3ccccc3)(c1ccccc1)CC - Sublethal observations / clinical signs:
--------------------------------------
Values used to Generate ECOSAR Profile
--------------------------------------
Log Kow: -1.139 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 1.437E+005 (mg/L, EPISuite WSKowwin v1.43 Estimate)
--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
******************************************************************************
| Not Related to an Existing ECOSAR Class Definition |
| |
| Estimates provided below use the Neutral Organics QSAR equations which |
| represent baseline toxicity potential (minimum toxicity) assuming a simple |
| non-polar narcosis model. Without empirical data on structurally similar |
| chemicals, it is uncertain if this substance will present significantly |
| higher toxicity above baseline estimates. |
******************************************************************************
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
--> Acid moeity found: Predicted values multiplied by 10
Neutral Organics-acid : Fish 96-hr LC50 1.9e+006 *
Neutral Organics-acid : Daphnid 48-hr LC50 8.07e+005 *
Neutral Organics-acid : Green Algae 96-hr EC50 1.81e+005 *
Neutral Organics-acid : Fish ChV 1.32e+005
Neutral Organics-acid : Daphnid ChV 35108.699
Neutral Organics-acid : Green Algae ChV 24892.484
Neutral Organics-acid : Fish (SW) 96-hr LC50 2.34e+006 *
Neutral Organics-acid : Mysid 96-hr LC50 1.46e+007 *
Neutral Organics-acid : Fish (SW) ChV 37434.910
Neutral Organics-acid : Mysid (SW) ChV 3.2e+006 *
Neutral Organics-acid : Earthworm 14-day LC50 12890.786
Note: * = asterisk designates: Chemical may not be soluble enough to
measure this predicted effect. If the effect level exceeds the
water solubility by 10X, typically no effects at saturation (NES)
are reported.
- Conclusions:
- Predicted EC50 values for fish (1.9e6 mg/l), daphnia (8.7e5 mg/l) and green algae (1.81e5 mg/l) show that fish is the least sensitive species compared to daphnia and algae.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- standard static acute fish toxicity test method; screening test without detailed information
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnows
- Strain: Rafinesque - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 12°C
- Details on test conditions:
- TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated Lake Huron water - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 726 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% c.i.
- Remarks:
- 1621 - 1831 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC10
- Effect conc.:
- 1 575 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% c.i.
- Remarks:
- 1340 - 1663 mg/L
- Duration:
- 96 h
- Dose descriptor:
- other: LC90
- Effect conc.:
- 1 891 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% c.i.
- Remarks:
- 1794 - 2205 mg/L
- Conclusions:
- The 96 h LC50 of ETPPAAc to Pimephales promelas was 1726 mg/L.
Referenceopen allclose all
Description of key information
- There is a supporting company report on a fish test with limited documentation stating a 96h-LC50 of 1726mg/L.
- According to a Ecosar QSAR calculation, fish is the least sensitive species compared to daphnia and algae.
- For the similar substance EthylTriphenylPhosphonium Bromide and MethylTriphenylPhosphonium Chloride, according to information published on Echa Homepage, fish is the least sensitive species compared to daphnia and algae.
With the information above, fish can is seen as less sensitive to EtPPAAc than daphnia and algae.
Following the threshold approach as described by (OECD 2012 FISH TOXICITY TESTING FRAMEWORK Series on testing and assessment No 171) and (guidance R7b, 2016, p47) a standard OECD 203 fish test can be avoided, if there is sufficient valid information that fish less sensitive than daphnia and algae.
In conclusion, there is sufficient information on sensitivity of fish compared to daphnia and algae to waive the performance of a standard fish test.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 726 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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