Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion:
- test substance (500mg, 4 hours, semi-occlusive) was slightly to moderately irritant to rabbits. [OECD TG 404, GLP]
Eye irritation:
- test substance was severly irritating to the eyes of rabbits. [OECD TG 405, GLP]
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- other: None. Substance was applied directly
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: 500 mg
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 11 d
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 11d
- Remarks on result:
- other: Max. duration: 10d; Max. value at end of observation period: 0
- Other effects:
- No further toxicological effects
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- Erythema and oedema were observed in all animals, so the substance is slightly to moderately irritating to the skin of rabbits.
- Executive summary:
The test substance was tested to be slightly to moderately irritating to the skin of rabbits ( 3 animals) in a GLP study according to OECD Guideline No. 404, but the effects are not sufficient to be classified as skin irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- not specified
- Amount / concentration applied:
- Amount applied: 100 mg
- Duration of treatment / exposure:
- 24 h
- Number of animals or in vitro replicates:
- 1
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- other: test terminated before reversibility could be determined.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: test terminated before reversibility could be determined.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: test terminated before reversibility could be determined.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: test terminated before reversibility could be determined.
- Other effects:
- No further toxicological observations.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- The substance is severely irritating to the eyes of rabbits.
- Executive summary:
The test substance was tested to be severly irritating to the eyes of rabbits ( 1 animals) in a GLP study according to OECD Guideline No. 405. Due to the severeness of the damages the test was cancelled after 24 h for reasons of animal protection.
Reference
Due to the severeness of the damages the test was cancelled after 24 h for reasons of animal protection.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion:
The test substance was tested to be slightly to moderately irritating to the skin of rabbits ( 3 animals) in a GLP study according to OECD Guideline No. 404, but the effects are not sufficient to be classified as skin irritant.
Eye irritation:
The test substance was tested to be severly irritating to the eyes of rabbits ( 1 animals) in a GLP study according to OECD Guideline No. 405 (due to the severeness of the damages the test was cancelled after 24 h for reasons of animal protection) and is therfore to be classified.
Justification for selection of skin irritation / corrosion endpoint:
GLP and guideline study
Justification for selection of eye irritation endpoint:
GLP and guideline study
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin irritation/corrosion:
The test material does not meet the criteria for classification and will not require labelling as irritating / corrosive to the skin in accordance with European Regulation (EC) No. 1272/2008.
Eye irritation:
The test material has the potential to seriously damage the eyes and is therefore classified in Category 1 (irreversible effects on the eye; H318: Causes serious eye damage) in accordance with European Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.