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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
- rat (Wistar SPF) m/f; LD50 >10000 mg/kg bw [OECD TG 401, GLP]
- mouse (SuPH-Velaz) m/f; LD50 = 10000 mg/kg bw [OECD TG 401, GLP]
Acute inhalation toxicity:
- rat m/f; LC50 >0.005 mg/L air (≙ 5mg/m^3; 7h) [OECD TG 403, GLP]
Acute dermal toxicity:
- rat (Wistar) m/f; LD50 >5000 mg/kg bw (24h) [OECD guideline 402, GLP]
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- mouse
- Strain:
- other: SuPH-Velaz
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- olive oil
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 10000 mg/kg bw, Number of animals: 5; Number of deaths: 0
Female: 10000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: No effects were observed.
- Body weight:
- No data
- Gross pathology:
- Effects on organs: Macroscopically no changes were observed.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- LD50 (mouse) = 10000 mg/kg bw
- Executive summary:
The acute oral toxicity of the test substance has been determined in a GLP test with mice according to OECD Guideline No. 401. The LD50 value was 10000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Exposure duration: 7 hours
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: for the product no aerodynamic diameter was used because the substance is a waxy solid.
- Details on inhalation exposure:
- 7 hour exposure, whole body
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- 0.005 mg/L air ≙ 5 mg/m^3 air
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 5 mg/m³ air
- Based on:
- test mat.
- Remarks:
- applicated concentration probably is the highest concentration which can be prepared (nearly saturated)
- Exp. duration:
- 7 h
- Remarks on result:
- other: No deaths occurred at this concentration. LC50 > 5 mg/m3
- Mortality:
- Male: 5 mg/m^3 air; Number of animals: 5; Number of deaths: 0
Female: 5 mg/m^3 air; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: The appearance and the behaviour of the treated animals was not influenced during the 14 days observation period.
- Body weight:
- The body weight was not influenced.
- Gross pathology:
- No treatment related effects were observed in none of the organs of the animals which were treated with test substance. A decrease of the somatomotoric activities was observed in the control groups and in the test groups as well. This observation was related to the decreased temperature in the exposure chamber.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- LC50 (rat) > 5 mg/m^3 air (7h)
- Executive summary:
The acute inhalation toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 403. No deaths occurred at the highest dose tested, so the LC50 value is > 5 mg/m3 air (7h).
Reference
Exposure chambers were used.
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 5 mg/m³
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- olive oil
- Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 5000 mg/kg bw; Number of animals; 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: No effects.
- Body weight:
- No data
- Gross pathology:
- Effects on organs: No effects.
- Other findings:
- Signs of toxicity (local): No effects.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- LD50 > 5000 mg/kg bw
- Executive summary:
The acute dermal toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 402. The LD50 value was > 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Additional information
Acute oral toxicity:
The acute oral toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 401. The LD50 value was > 10000 mg/kg bw. A similar result has been obtained in a GLP test with mice according to OECD Guideline No. 401. The LD50 value was 10000 mg/kg bw and the test subtstance does therefore not need to be classified according to Regulation 1272/2008/EC.Acute inhalation toxicity:
The acute inhalation toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 403. No deaths occurred at the highest dose tested, so the LC50 value is > 5 mg/m3air (7h) and the test subtstance does therefore not need to be classified according to Regulation 1272/2008/EC.
Acute dermal toxicity:
The acute dermal toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 402. The LD50 value was > 5000 mg/kg bw and the test subtstance does therefore not need to be classified according to Regulation 1272/2008/EC.
Justification for selection of acute toxicity – oral endpoint
There are two equally reliable (GLP and guideline) studies available. Further, the results from both studies are almost identical, so the endpoint selection has no influence on the classification of the substance, as both lead to the conclusion that the test substance does not need to be classified.
Justification for selection of acute toxicity – inhalation endpoint
GLP and guideline study
Justification for selection of acute toxicity – dermal endpoint
GLP and guideline study
Justification for classification or non-classification
Acute oral toxicity:
The test material does not meet the criteria for classification and will not require labelling for oral toxicity in accordance with European Regulation (EC) No. 1272/2008.
Acute inhalation toxicity:
The test material does not meet the criteria for classification and will not require labelling for inhalation toxicity in accordance with European Regulation (EC) No. 1272/2008.
Acute dermal toxicity:
The test material does not meet the criteria for classification and will not require labelling for dermal toxicity in accordance with European Regulation (EC) No. 1272/2008.
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