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EC number: 283-634-2 | CAS number: 84696-15-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Zingiber officinalis, Zingiberaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ginger, ext.
- EC Number:
- 283-634-2
- EC Name:
- Ginger, ext.
- Cas Number:
- 84696-15-1
- Molecular formula:
- N/A
- IUPAC Name:
- Essential oil extract of Zingiber officinalis (Zingiberaceae) root GINGER ESSENTIAL OIL Ginger Oil Ginger Oleoresin Ginger, ext Ginger, ext. Ginger, Extrakt HE Zingiber officinalis INCI name: Zingiber Officinale (Ginger) Root Extract OILS, GINGER Reaction mass of camphene and pin-2(3)-ene and 7-methyl-3-methyleneocta-1,6-diene and pin-2(10)-ene and cineole and [S-(R*,S*)]-5-(1,5-dimethylhexen-4-yl)-2-methyl-1,3-cyclohexa-1,3-diene and (R)-p-mentha-1,8-diene Zingiber officinalis, Zingiberaceae.
1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24 and 48 h
- Post exposure observation period:
- 24h
Test conditions
- Test temperature:
- 21 °C ± 1 °C,
- pH:
- 7.8 ± 0.5
- Dissolved oxygen:
- Dissolved oxygen was > 7 mg/l (minimum acceptable value)
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- other: Cv
- Remarks:
- Cv%=|Tt48−Tt0|/Tt48 ×100 Tt48 is the titer determined at 48 hours, Tt 0 is the titer determined at 0 hours
- Effect conc.:
- ca. 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- 3.08%
- Basis for effect:
- mobility
- Details on results:
- At the end of the definitive test, EC50 was calculated using the EPA software PROBIT. 95% confidence limits was also calculated. The PROBIT elaboration was attached to the raw data.
EC50: 8.752 mg/l (confidence limits 7.022 mg/l – 10.709 mg/l)
Any other information on results incl. tables
Test Solution | %Immobilization (24 h) |
%Immobilization (48 h) |
Initial pH | Final pH | Initial Dissolved Oxygen | Final Dissolved Oxygen |
C1 (500 mg/l) |
80 % | 100 % | 7.83 | 7.52 | 8.89 | 9.34 |
C2 (250 mg/l) |
50 % | 90 % | 7.82 | 7.43 | 8.56 | 8.90 |
C3 (125 mg/l) |
30 % | 70 % | 7.83 | 7.36 | 9.24 | 9.95 |
C4 (62.5 mg/l) |
10 % | 30 % | 7.92 | 7.29 | 9.60 | 9.52 |
C5 (31.3 mg/l) |
0 % | 0 % | 7.99 | 7.23 | 9.17 | 9.72 |
Negative Control | 0 % | 0 % | 8.03 | 7.62 | 8.78 | 9.11 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- the concentrations used in this test were: 3.2 mg/l – 1.8 mg/l – 1 mg/l – 0.56 mg/l – 0.32 mg/l. Results of the tests were reported in the control chart 775/GxP. The calculated EC50 resulted between 0.6 mg/l and 2.1 mg/l.
- Conclusions:
- According to OECD 202:2004, under the test conditions applied, the EC50 of the test substance is calculated as 8.752 mg/l.
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