Registration Dossier
Registration Dossier
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EC number: 814-084-9 | CAS number: 38129-46-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- methyl 3-[(3-methoxy-3-oxopropyl)(2-phenylethyl)amino]propanoate
- EC Number:
- 814-084-9
- Cas Number:
- 38129-46-3
- Molecular formula:
- C16 H23 N O4
- IUPAC Name:
- methyl 3-[(3-methoxy-3-oxopropyl)(2-phenylethyl)amino]propanoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch OP 3/88
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.35 ml applied on a 6cm2 area
- Duration of treatment / exposure:
- single exposure - 4 hours
- Observation period:
- 1 to 72h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Score:
- ca. 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No irritation up to 72h. The 428 DIESTER is considered to be non irritant by cutaneaous route.
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