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EC number: 629-704-1 | CAS number: 226995-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The irritant or corrosive effects of the substance when applied dermally was evaluated in three New Zealand White rabbits according to the OECD TG 404. Three healthy male rabbits were dosed dermally with the substance (0.5mL/animal) to one intact site/rabbit. The substance was kept in contact with the skin for 4 hours at which time the wrappings were removed. Erythma was absent to barely perceptible at 60 minutes following patch removal and absent at 24, 48 and 72 hours. Oedema was absent at all observation periods. There were no abnormal physical signs noted during the observation period. All body weight changes were as expected. It is concluded that the substance is not a dermal irritant.
In a reliable in vivo eye irritation study New Zealand White rabbits (n=6) were exposed to the substance by instillation of the substance into one eye. The corresponding eye of the same animal was left untreated and acted as concurrent control. The eyes were examined at1, 2 and 3 days post-administration of substance.Four of six eyes appeared normal at each observation period. Slight conjunctival irritation, noted in 2/6 eyes, cleared by day 2. There were no abnormal systemic observations.The substance is not an eye irritant under the conditions of this study.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 April 2001 - 06 April 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- July 17, 1992
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Storage: Room temperature and humidity
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Pre-test body weight range of the male rabbits was 2.2-2.5 kg.
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL/rabbit
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours post-treatment.
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Erythma was absent to barely perceptible at 60 minutes following patch removal and absent at 24, 48 and 72 hours. Oedema was absent at all observation periods. There were no abnormal physical signs noted during the observation period. All body weight changes were as expected.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not a dermal irritant.
- Executive summary:
The irritant or corrosive effects of the substance when applied dermally was evaluated in three New Zealand White rabbits according to the OECD TG 404. Three healthy male rabbits were dosed dermally with the substance (0.5mL/animal) to one intact site/rabbit. The substance was kept in contact with the skin for 4 hours at which time the wrappings were removed. Dermal reactions were scored at 60 minutes following patch removal. Reactions were scored again at 24, 48 and 72 hours following patch removal. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction at these time periods. Erythma was absent to barely perceptible at 60 minutes following patch removal and absent at 24, 48 and 72 hours. Oedema was absent at all observation periods. There were no abnormal physical signs noted during the observation period. All body weight changes were as expected. It is concluded that the substance is not a dermal irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 August 1997 - 21 August 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- other: FHSA 16 CFR 1500.42
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Stored at room temperature and humuidty.
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- The pre-test body weight range was 2.1 - 2.3 kg.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- A few seconds
- Observation period (in vivo):
- 1, 2 and 3 days post-administration of substance.
- Number of animals or in vitro replicates:
- Six
- Irritation parameter:
- overall irritation score
- Basis:
- animal: 2 animals
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 2 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 2 eyes
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 2 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all 6 eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: all 6 eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 4 eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: all 6 eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Four of six eyes appeared normal at each observation period. Slight conjunctival irritation, noted in 2/6 eyes, cleared by day 2. There were no abnormal systemic observations.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not an ocular irritant.
- Executive summary:
In an in vivo eye irritation study New Zealand White rabbits (n=6) were exposed to the substance by instillation of the substance into one eye. The corresponding eye of the same animal was left untreated and acted as concurrent control. The eyes were examined at 1, 2 and 3 days post-administration of substance. Four of six eyes appeared normal at each observation period. Slight conjunctival irritation, noted in 2/6 eyes, cleared by day 2. There were no abnormal systemic observations. The substance is not an eye irritant under the conditions of this study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the findings of a reliable in vivo skin irritation/corrosion study and an in vivo eye irritation study conducted on the substance, classification of the substance is not justified.
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