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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

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Endpoint:
activated sludge respiration inhibition testing
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
not specified
Analytical monitoring:
no
Test organisms (species):
activated sludge of a predominantly domestic sewage
Details on inoculum:
Source: Municipal wastewater treatment plant.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 h
Key result
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Validity criteria fulfilled:
yes
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
other: DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
Principles of method if other than guideline:
DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Pseudomonas putida
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
16 h
Key result
Duration:
16 h
Dose descriptor:
other: toxicity threshold
Effect conc.:
ca. 1 050 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: mean extinction value
Validity criteria fulfilled:
not applicable
Conclusions:
The toxicity threshold (TT) of 2-propanol to Pseudomonas putida (cell multiplication) is 1050 mg/l based on a 16 h test.

Description of key information

No studies were conducted on the target substance, Bis[[2,2',2''-nitrilotris[ethanolato]](1-)-N,O]bis(propan-2-olato)titanium. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic 2-propanol and 2,2',2''-Nitrilotriethanol (triethanolamine). The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of triethanolamine and 2-propanol are well-investigated are used for CSA.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information