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Diss Factsheets
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EC number: 268-732-5 | CAS number: 68134-15-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-01-06 to 1992-01-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not applicable
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Direct dispersion in water
- Controls: 1 replicate test water only)
- Evidence of undissolved material: Not specified - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Parkwood Trout Farm, Kent, U.K.
- Length at study initiation: 5.4 +/- 0.5 cm
- Weight at study initiation: 1.77 +/- 0.33 g
- Medication: None
- Mortalities: Zero in the 7 days prior to the start of the test - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Not performed
- Hardness:
- 50 mg/L as CaCO3 (dilution water)
- Test temperature:
- 14 °C
- pH:
- Not specified
- Dissolved oxygen:
- Not specified
- Salinity:
- Not applicable
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Nominal: 10 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Not specified
- Aeration: Yes
- Renewal rate of test solution: Daily renewal
- No. of vessels per concentration: 2
- No. of vessels per control: 1
- Animals per test vessel: 10
- Biomass loading rate: 0.89 g bodyweight/litre
TEST MEDIUM / WATER PARAMETERS
- Source of dilution water: Dechlorinated tap water (prepared with Sodium thiosulphate)
EFFECT PARAMETERS MEASURED: Mortality after 24, 48, 72 and 96 hours of exposure
TEST CONCENTRATIONS
- Range finding study : Yes
- Test concentrations in range finding study: 1, 10 and 100 mg/L
- Control: Blank control
- Initial population: 2 animals/vessel
- Results used to determine the conditions for the definitive study: Yes - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Table 1: Results of the main study
Concentration (mg/L) Cumulative Mortality (initial population = 10) 24 hours 48 hours 72 hours 96 hours Control 0 0 0 0 10 R1 0 0 0 0 10 R2 0 0 0 0 R1 - R2: Replicates R1 - R2
Table 2: Results of the range finding study
Concentration (mg/L) Cumulative Mortality (initial population = 2) 24 hours 48 hours 72 hours 96 hours Control 0 0 0 0 1.0 0 0 0 0 10 0 0 0 0 100 2 2 2 2 - Validity criteria fulfilled:
- not specified
- Conclusions:
- In an Acute Toxicity Test similar to OECD Guideline 203, the 96-h LC50 of the test item was determined to be > 10 mg/L.
- Executive summary:
In a semi-static test similar to OECD Guideline 203, the acute toxicity of the test item to fish (Onchorhynchus mykiss) was assessed at a limit concentration of 10 mg/L (two replicates) over a duration of 96 hours. In addition, a negative control (without the test item, 1 replicate) was performed. As test medium dechlorinated tap water was used. Test solutions were prepared by direct dispersion of the test item in water. As test parameter, mortality was recorded after 24, 48, 72 and 96 hours of exposure. In result, the 96-h LC50 of the test item was determined to be > 10 mg/L.
Reference
Description of key information
In an Acute Toxicity Test similar to OECD Guideline 203, the 96-h LC50 of the test item was determined to be > 10 mg/L.
Key value for chemical safety assessment
Additional information
In a semi-static test similar to OECD Guideline 203, the acute toxicity of the test item to fish (Onchorhynchus mykiss) was assessed at a limit concentration of 10 mg/L (two replicates) over a duration of 96 hours. In addition, a negative control (without the test item, 1 replicate) was performed. As test medium dechlorinated tap water was used. Test solutions were prepared by direct dispersion of the test item in water. As test parameter, mortality was recorded after 24, 48, 72 and 96 hours of exposure. In result, the 96-h LC50 of the test item was determined to be > 10 mg/L.
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