Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-156-4 | CAS number: 68411-97-2
Endpoint summary
Administrative data
Description of key information
Glycine, N-methyl-, N-coco acyl derivatives (CAS 68411-97-2) has a low potential for bioaccumulation.
Additional information
Glycine, N-methyl-, N-coco acyl derivatives (CAS 68411-97-2) has a low potential for bioaccumulation at environmentally relevant pH based on its log D values (used for ionisable substances instead of log Kow) of 0.61 to 1.52 at pH 7 and -0.30 to 0.63 at pH 9 (SPARC v4.6), indicating low lipophilicity at environmentally relevant pH values of 7 to 9. According to REACh regulation (EC) No 1907/2006, substances with log Kow ≤ 3.0 have a low potential for bioaccumulation. Thus, further testing is not required in accordance with Annex IX, column 2, 9.3.2. of Regulation (EC) No. 1907/2006.
Furthermore, the predicted BCF values also indicate that the potential for bioconcentration in aquatic organisms is low. The estimated BCF values are 3.16 L/kg wet-wt (BCFBAF model v3.01 regression-based), 184.9 – 194.5L/kg wet-wt (BCFBAF model v3.01 Arnot-Gobas, including biotransformation upper trophic) and 3.0 – 74.0 L/kg wet-wt (VEGA v1.2.3, CAESAR, Meylan and KNN models), which are clearly below the cut-off values of 2000 L/kg wet-wt for bioaccumulative and 5000 L/kg wet-wt for very bioaccumulative substances, as laid down by section 1 of Annex XIII of REACH Regulation EC) No 1907/2006. In addition, toxicokinetic considerations with regard to absorption, distribution, metabolisation and excretion of the substance provide further evidence for a low potential for bioaccumulation. While absorption after oral uptake is considered likely, systemic distribution, accumulation and metabolisation of the substance is not anticipated and urinary excretion is expected to be an important and rapid excretion pathway based on experimental mammalian studies with structurally similar substances (for further details, please refer to the toxicokinetic statement in IUCLID section 7.1).
Moroever, the substance is characterized by a water solubility of < 0.5 mg/L (20 °C, OECD 105) and ready biodegradability. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological sewage treatment plants (STPs) (ECHA, 2016). Therefore, only negligible concentrations of the substance are likely to be released into the environment through conventional STPs, if at all, and whatever fraction is released will not persist. Thus, exposure of aquatic organisms and bioavailability in the environment is expected to be low.
In conclusion, the potential for bioaccumulation is expected to be low for Glycine, N-methyl-, N-coco acyl derivatives (CAS 68411-97-2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
