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EC number: 257-843-4 | CAS number: 52315-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- N6-(1-oxododecyl)-L-lysine
- EC Number:
- 257-843-4
- EC Name:
- N6-(1-oxododecyl)-L-lysine
- Cas Number:
- 52315-75-0
- Molecular formula:
- C18H36N2O3
- IUPAC Name:
- N6-(1-oxododecyl)-L-lysine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Name: Nε-Lauroyl-L-Lysine
Supplier: Ajinomoto Co., Inc.
Molecular weight: 328.50
Lemon yellow powder with a purity of 95%
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Species / strain / cell type:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 0, 5, 10, 50, 100, 500, 1000 and 5000 ug/plate
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Remarks:
- DMSO
- Negative solvent / vehicle controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- 2-nitrofluorene
- N-ethyl-N-nitro-N-nitrosoguanidine
- furylfuramide
- other: 2-aminoanthracene
- Details on test system and experimental conditions:
- The test was performed using the pre-incubation method with and without metabolic activation.
- Evaluation criteria:
- The results are judged as positive for inducibility of gene mutation when the number of revertant colonies per plate (mean) increases dose-dependently 2-fold or greater compared with that in the negative control. It is judged that the study has been performed satisfactorily when the number of revertant colonies in the negative and positive controls is within the range.
- Statistics:
- not further specified
Results and discussion
Test results
- Key result
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538 and Escherichia coli WP2uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- The test item did not induce gene mutationn in bacteria.
- Executive summary:
The test item was tested in a study comparable to OECD Guideline 471 with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 as well as with Escherichia coli WP2uvrA using the pre-incubation method with and without metabolic activation. The test was performed with levels of 0 – 5000 ug/plate. A growth inhibition was observed at 5000 ug/plate in TA1535, TA98 and TA1537 without metabolic activation. A precipitation was not observed up to 5000 ug/plate both with and without metabolic activation.
Therefore, the test item did not induce gene mutations in bacteria.
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