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EC number: 203-517-1 | CAS number: 107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16.02.1998 to 20.02.1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- GLP compliance:
- yes
- Remarks:
- Department of Toxicology of BASF Aktiengesellschaft, 67056 Ludwigshafen/Rhein (Germany)
Test material
- Reference substance name:
- 3,7-dimethyloctane-1,7-diol
- EC Number:
- 203-517-1
- EC Name:
- 3,7-dimethyloctane-1,7-diol
- Cas Number:
- 107-74-4
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 3,7-dimethyloctane-1,7-diol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: BASF AG, Batch No.: 2/10/97
- Expiration date of the lot/batch: not reported
- Purity test date: not reported
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, exclusion of light
- Stability under test conditions: yes
- Solubility and stability of the test substance in the solvent/vehicle: water solubility: 30.1 g/L at 25°C, stability under test conditions was proved by reanalysis
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no
- Preliminary purification step (if any): no
FORM AS APPLIED IN THE TEST (if different from that of starting material): aqueous solution
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- GC/FID
- Details on sampling:
- - Concentrations: 0, 21.5, 46.4, 100, 215, 464, 1000, 2150 g/L nominal
- Sampling method: extraction of the aqueous phase using dichloromethane
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish (Brachydanio rerio Ham. and Buch.)
- Source: Bio International B.V., NJ Horn; Netherlands; For the added concentrations: Bio International B.V., Roermond; Netherlands
- Age at study initiation (mean and range, SD): ca. 6 months
- Length at study initiation (length definition, mean, range and SD): for the added concentrations: 3.07 (2.6-3.4) cm
- Weight at study initiation (mean and range, SD): for the added concentrations: 0.173 (0.10-0.30) g
- Method of breeding: The fish were kept in a flow-through tank in tap water, not chlorinated, passed through a charcoal filter and aerated with oil-free air
ACCLIMATION
- Acclimation period: 1 month
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: TETRA MIN standard feed for aquarium fish, TETRA-Werke, Melle, Germany, ad libitum; and on workdays generally additionally live brine shrimp (artemia)
- Feeding frequency during acclimation: TETRA MIN standard feed for aquarium fish, TETRA-Werke, Melle, Germany, ad libitum; and on workdays generally additionally live brine shrimp (artemia)
- Health during acclimation (any mortality observed): mortality during the last 14 d: 1.5%; for the added concentrations: 0%
FEEDING DURING TEST
- Food type: TETRA MIN standard feed for aquarium fish, TETRA-Werke, Melle, Germany, ad libitum; and on workdays generally additionally live brine shrimp (artemia)
- Amount: ad libitum; and on workdays generally additionally live brine shrimp (artemia)
- Frequency: ad libitum; and on workdays generally additionally live brine shrimp (artemia)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 250 mg/L CaCO3
- Test temperature:
- 22°C
- pH:
- 8.3-8.6 (in all test vessels)
- Dissolved oxygen:
- 7.5-9.0 (in all test vessels)
- Nominal and measured concentrations:
- nominal:
0, 21.5, 46.4, 100, 215, 464, 1000, 2150 mg/L
measured
after 1 h: 0, 20.85, 43.35, 99.5, 228, 442, 964, 2182 mg/L (mean of two measurements)
m - Details on test conditions:
- TEST SYSTEM
- Test vessel: aquaria
- Type (delete if not applicable): open / closed not reported
- Material, size, headspace, fill volume: glass/15.84 L/-/10 L
- Aeration: yes
- Type of flow-through (e.g. peristaltic or proportional diluter): test conducted under static conditions
- Renewal rate of test solution (frequency/flow rate): test conducted under static conditions
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.2 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: municipal water of the city of Frankenthal, not chlorinated and passed through a charcoal filter aerated
- Intervals of water quality measurement: intervals not reported (water quality was checked regularly)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/8 h dark
- Light intensity: not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, behaviour/symptoms
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.2
- Range finding study: performed
- Test concentrations: not reported
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 215 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 464 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 198 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 415.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 986.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: at concentrations >=464 mg/L nominal and exposure times >24 h, apathy, convulsion, and tumbling were observed
- Mortality of control: 0
- Other adverse effects control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Reported statistics and error estimates:
- Probit analysis was performed for calculation of toxicity values (NOEC, LC).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute toxicity test with fish, 96 h LC50 values based on nominal and measured concentrations were determined to be ca. 464 and 415.5 mg/L, respectively.
- Executive summary:
The acute toxicity of hydroxycitronellol to fish was investigated in a study conducted according to OECD Guideline 203 (Fish, Acute Toxicity Test; 1992) and EU Method C.1 (Acute Toxicity for Fish; 1992). 10 Fish were exposed to 8 nominal concentrations ranging from 0 to 2150 mg/L for 96 h under static conditions. Mortality and behaviour/symptoms were recorded. The test substance concentrations were measured via GC/FID. The analytically determined concentrations were initially in the range of 93 -108% and after about 96 h between 73 and 100% of the nominal concentrations. The 96 h LC50 values based on nominal and measured concentrations were determined to be ca. 464 and ca. 415.5 mg/L, respectively.
The study is well documented and can be classified as reliable without restrictions satisfying the guideline requirements for an acute toxicity study with fish.
Results Synopsis
Test organism size/age: Brachydanio rerio (new name: Danio rerio; 6 months old, length: 3.07 cm; weight: 0.173 g)
Test Type: static
96 h LC50: ca. 464 mg/L (nominal)96 h LC50: ca. 415.5 mg/L (measured)
Endpoint(s) Effected: mortality, behaviour/symptoms
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