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EC number: 229-653-1 | CAS number: 6640-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 MAR 2013 - 20 JUN 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- European Commission Regulation (EC) No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- 43 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- The water solubility of the test item at 20 °C is 43 g/L.
- Executive summary:
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a non-GLP study. The water solubility cs of the test item at a temperature of 20 °C was determined via HPLC with the flask method to be (without correction for the purity): cs = 43 g/L (± 1 g/L).
Reference
Preliminary Visual Estimation of the Water Solubility
Different amounts of the test item and water were treated with ultrasound or stirred at room temperature until the mixture appeared dissolved or the water solubility could be estimated to be below 10 mg/L.
Amount of test item in mg |
Total volume in mL |
Appearance of mixture |
85.9 |
0.1 |
undissolved1) |
0.5 |
undissolved1) |
|
1.0 |
dissolved1) |
1): After adding the indicated amount of water, the solution was treated with ultrasound for 10 minutes.
According to the preliminary visual estimation the water solubility of the test item is above 86 g/L. Consequently the flask method was performed as main test.
Due to the high water solubility it had to be tested which amount of the test item could be stirred in a defined volume of water.
Amount of test item in g |
Total volume in mL |
Appearance of mixture |
4.83 |
1 |
could not be stirred at room temperature |
2 |
could not be stirred at room temperature |
|
3 |
could not be stirred at room temperature |
|
3.5 |
could be stirred at room temperature |
|
5 |
could not be stirred at 20 °C |
|
6 |
could not be stirred at 20 °C |
|
6.5 |
could be stirred at 20 °C |
The stirring test showed that a test item water mixture with a concentration of 743 g/L test item can be used for the flask method.
Flask method
Experiment |
A |
B |
C |
D (blank) |
Amount of test Item (g) |
9.69 |
9.66 |
9.65 |
-- |
Amount of destilled water (ml) |
13 |
13 |
13 |
13 |
Stirring time at 30 °C (h) |
24 |
48 |
72 |
72 |
pH at 23.2-23.5 °C |
9.5 |
9.4 |
9.5 |
6.9 |
Aliquot of the flasks (mL) |
0.1 |
0.1 |
0.1 |
0.1 |
Dilution (mL) |
25 |
25 |
25 |
25 |
Aliquot of the diluted sample (mL) |
1 |
1 |
1 |
1 |
Dilution (mL) |
25 |
25 |
25 |
25 |
Dilution factor |
6250 |
6250 |
6250 |
6250 |
Measured concentration (mg/L) |
6.69/6.69 |
6.96/7.01 |
6.92/6.88 |
--/-- |
Mean concentration (mg/L) |
6.69 |
6.98 |
6.90 |
-- |
Water solubility (g/L)1) |
41.8 |
43.7 |
43.1 |
-- |
1)At the end of the equilibration time at 20 °C the test item water mixtures were no longer stirrable. It was assumed
that this had no effect on the final result as the stirring times of 24, 48 and 72 hours were reached.
The water solubility of the test item at 20 °C was determined to be 43 g/L (SD = 1 g/L).
The water solubility is calculated from the measured and unrounded concentration values and not from the rounded values given in Table before.
Description of key information
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a non-GLP study. The water solubility csof the test item at a temperature of 20 °C was determined via HPLC with the flask method to be (without correction for the purity): cs= 43 g/L (± 1 g/L).
Key value for chemical safety assessment
- Water solubility:
- 43 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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