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EC number: 232-030-7 | CAS number: 7783-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- for read across substance
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two short term toxicity to aquatic invertebrate for the test chemical :
1.Acute immobilization of Daphnia was performed for test material
2.Acute toxicity testing of test matrial on Daphnia magna using the 48 h Acute Immobilisation Test - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: Ferric hypophosphite
- IUPAC name: iron(3+) ion triphosphinate
- Molecular formula: FeO6P3
- Molecular weight: 250.8084 g/mole
- Smiles : [Fe+3].[O-]P=O.[O-]P=O.[O-]P=O
- Inchl: 1S/Fe.3H3O2P/c;3*1-3-2/h;3*3H2,(H,1,2)/q+3;;;/p-3
- Substance type: Inorganic
- Physical state: Solid powder (white to grey) - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 1 . <72 h old neonates from the acute
immobilization tests.
20 actively swimming neonates from each test concentration were
collected and transferred into clean lake water
- Type and amount of food: Pseudokirchneriella subcapitata
- Frequency: once per day
2.Age: <24 h old, 4 replicates of 5 neonates
20 animals were tested - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- 1.10 mg/l , 100 mg/l , 1000 mg/l
2.0.01, 0.1, 1, 10 and 100 mg /L - Details on test conditions:
- 1.Every individual was exposed separately in a 40 ml vessel
- Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7 for Read across 2
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Read across 1
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Read across 2
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The test chemical Ferric hypophosphite is not likely to be toxic to Daphnia magna atleast in the dose range of 100-1000 mg/l
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of Daphnia magna of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:
1. The acute immobilization of Daphnia magna was performed using test material for 48h.The acute immobilization tests showed that in general the test material were not acutely toxicto D. magna: even at 100 ppmDue to the low toxicity of magnetite, we also evaluated the toxic
effects at 1000 ppm although according to the test guidelines (OECD). However, even at 1000 ppm the 50% inhibitory effect was not observed. Hence , The effect concentration was observed to be > 1000 mg/l.
2.The immobilization test of Daphnia magna was performed for test material as per OECD 202 . Groups of 20 water fleas, Daphnia magna, (< 24 h old, 4 replicates of 5 neonates) were exposed to uncontaminated water, 0.01, 0.1, 1, 10 and 100 mg as/L under static conditions in a range finding test.The duration of the test was 48 h.The effect concentration of test material on Daphnia magna was observed to be >100 mg/l.
Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is greater than 100 mg/L. Thus, comparing this value with the criteria of CLP regulation,Ferric hypophosphite cannot be classifiedfor short term toxicity for aquatic invertebrates .Hence,based on the data available for the structurally and functionally similar
read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of 100 mg/L .
Reference
Description of key information
Short-term toxicity to aquatic invertebrates:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of Daphnia magna of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:
1. The acute immobilization of Daphnia magna was performed using test material for 48h.The acute immobilization tests showed that in general the test material were not acutely toxicto D. magna: even at 100 ppmDue to the low toxicity of magnetite, we also evaluated the toxic
effects at 1000 ppm although according to the test guidelines (OECD). However, even at 1000 ppm the 50% inhibitory effect was not observed. Hence , The effect concentration was observed to be > 1000 mg/l.
2.The immobilization test of Daphnia magna was performed for test material as per OECD 202 . Groups of 20 water fleas, Daphnia magna, (< 24 h old, 4 replicates of 5 neonates) were exposed to uncontaminated water, 0.01, 0.1, 1, 10 and 100 mg as/L under static conditions in a range finding test.The duration of the test was 48 h.The effect concentration of test material on Daphnia magna was observed to be >100 mg/l.
Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is greater than 100 mg/L. Thus, comparing this value with the criteria of CLP regulation,Ferric hypophosphite cannot be classifiedfor short term toxicity for aquatic invertebrates .Hence,based on the data available for the structurally and functionally similar
read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of 100 mg/L .
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 000 mg/L
Additional information
Short-term toxicity to aquatic invertebrates:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of Daphnia magna of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:
1. The acute immobilization of Daphnia magna was performed using test material for 48h.The acute immobilization tests showed that in general the test material were not acutely toxicto D. magna: even at 100 ppmDue to the low toxicity of magnetite, we also evaluated the toxic
effects at 1000 ppm although according to the test guidelines (OECD). However, even at 1000 ppm the 50% inhibitory effect was not observed. Hence , The effect concentration was observed to be > 1000 mg/l.
2.The immobilization test of Daphnia magna was performed for test material as per OECD 202 . Groups of 20 water fleas, Daphnia magna, (< 24 h old, 4 replicates of 5 neonates) were exposed to uncontaminated water, 0.01, 0.1, 1, 10 and 100 mg as/L under static conditions in a range finding test.The duration of the test was 48 h.The effect concentration of test material on Daphnia magna was observed to be >100 mg/l.
Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is greater than 100 mg/L. Thus, comparing this value with the criteria of CLP regulation,Ferric hypophosphite cannot be classifiedfor short term toxicity for aquatic invertebrates .Hence,based on the data available for the structurally and functionally similar
read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of 100 mg/L .
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