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Diss Factsheets
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EC number: 233-251-1 | CAS number: 10101-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.05 mg/m³
- Most sensitive endpoint:
- neurotoxicity
DNEL related information
- DNEL derivation method:
- other: Based on respirable IOELV for manganese
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.05 mg/m³
- Most sensitive endpoint:
- neurotoxicity
DNEL related information
- DNEL derivation method:
- other: Based on respirable IOELV for manganese
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
Manganese sulphate and manganese dichloride read-across toxicity data have been where data on the registered substance are not available. Read-across is considered justified as manganese is considered to be the main driver of the toxicity of the registered substance and the soluble sulphate and chloride salts present a "worst-case" in view of their very high water solubility and bioavailability.
DNEL derivation
The critical local (dermal, respiratory tract) effects of exposure to sodium permanganate will be irritation / corrosion at the site of contact due to the corrosive nature of the substance. These effects must be managed by the use of PPE and / or engineering controls to eliminate the potential for dermal exposure to high concentrations of the substance. Local irritation may not occur following dermal or inhalation exposure to low concentrations of the substance, however this cannot be quantified and therefore DNEL values for local effects are not proposed.
The critical effect of exposure to the substance, based on extensive data from other manganese compounds, is assumed to be neurotoxicity. Neurotoxicity has not been specifically investigated for the substance, however it is assumed that will occur by analogy with other inorganic manganese compounds. While the majority of effects in the studies with the substance are consistent with local irritation, findings from the reproduction range-finding study indicate neurological effects in offspring. It is therefore concluded that neurotoxicity is the critical effect relevant to the derivation of systemic DNEL values.
The SCOEL (2011) has published a consultation on the derivation of IOEL values for manganese and inorganic manganese compounds. This consideration is based on a comprehensive review of the extensive database for this group of substances which is beyond the scope of this IUCLID dossier.
The SCOEL (2011) conclude that, although manganism has long been recognised as being associated with high occupational manganese exposures, recent attention has focused on more subtle neurofunctional effects that may occur at lower levels of exposure. A review of the evidence, supported by additional studies published subsequently led to the concliusion that, in humans, the critical effects associated with contemporary (low) occupational exposure to manganese are neurological. These subtle neurological effects, that is, principally small sub-clinical neuromotor effects, are considered to be of sufficient concern to warrant the establishment of an appropriate occupational exposure standard. A limited number of longitudinal investigations on these more subtle effects indicate a stability (lack of progression) of adverse effects when exposure is reduced, but also indicate that such effects, once established, may not be reversible. Furthermore, most of the neurofunctional effects observed reflect changes in neuromotor function, as is the case with overt manganism. There are a sufficient number of well-conducted studies on workers exposed to known or reasonably well-estimated amounts of manganese to use human data for the derivation of a health-based Indicative Occupational Exposure Limit Value (IOELV). SCOEL highlighted that it was not possible to identify a single critical study as the best basis for DNEL derivation, but used a global approach based on the entire dataset.
The indicative respirable IOELV is 0.05 mg/m3 and an inhalable IOELV is 0.2 mg/m3 for manganese and manganese inorganic compounds. While recommending these values, SCOEL recognised that the overall systemic absorption of coarser particles (> respirable) is probably substantially lower than for the respirable fraction. Thus, SCOEL recommended both a respirable and an inhalable IOELV which would need to be observed conjointly. It was recommended that workplaces should, as a default procedure, measure both respirable and inhalable manganese to ensure compliance with both limits. This will protect workers exposed to respirable manganese, such as welders, and also workers exposed to inhalable manganese in workplaces with low fractions of respirable manganese, likely the case for sodium permanganate. In each specific working circumstance, professional judgement should however, be applied to select the most appropriate fraction to be measured. It was considered that a STEL was not required. Dermal absorption of manganese is likely to be negligible (and exposure limited due to corrosivity), therefore systemic dermal DNEL values have been derived only as precautionary.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.