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Diss Factsheets
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EC number: 601-601-6 | CAS number: 119345-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human study without test guidelines that is not applicable to GLP study conduct. Sufficient data are available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Tested according to the method of Shelanski and Shelanski (proceedings of the Scientific Section of the Toilet Goods Association, NO. 19, May, 1953)
- GLP compliance:
- no
- Remarks:
- not applicable to human studies
Test material
- Reference substance name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- EC Number:
- 601-601-6
- Cas Number:
- 119345-04-9
- Molecular formula:
- C24H32O7S2Na2
- IUPAC Name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- Details on test material:
- Dowfax 2A1
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- 50 human subjects, 25 males and 25 females.
- Clinical history:
- No data
- Controls:
- No data
- Route of administration:
- dermal
- Details on study design:
- Dowfax 2A1 as a 15% aqueous solution was tested according to the method of Shelanski and Shelanski (proceedings of the Scientific Section of the T Toilet Goods Association, NO. 19, May, 1953). This test involves the application of the test material 5 times a week for 3 weeks to a group of 50 human subjects, 25 males and 25 females for 24 hours. 2 to 3 weeks after this routine a challenge application is made to each person at the same site.
A response after the initial application is interpreted as indicating the potential of the material to produce primary irritation. An increase in the intensity of the response occurring later in the routine of exposures indicates the ability of the material to cause fatiguing of the skin. A response after the challenge application greater iin intensity than that observed initially indicates the potential ability of the material to produce an allergenic response.
Results and discussion
- Results of examinations:
- Number of subjects negative throughout: 12
Number of subjects reacting: 38
Number of subjects showing 1+ maximum reactions: 37
Number of subjects showing 2+ maximum reactions:. 1
Any other information on results incl. tables
Morris V. Shelanski, M.D, C,M,, Director of Industrial Toxicology Laboratories.
"Dowfax 2A1- This material is neither a primary irritant nor a sensitizer. It may be considered a mild fatiguing agent. This material is safe to use when in contact with the human skin since it is a milder fatiguing agent than 5% weight by volume solution of ordinary commercial soap. "
Joseph V. Klauder, M.D., Consultant Dermatologist who personally examined the subjects during this test period.
"In the case of material 2 (Dowfax 2A1 ) with two exceptions positive reaction comprised 1+ grade and totalled 102 of the 750 applications. There was no reaction after the initial application, hence, no evidence of primary irritant action. The evidence of fatiguing action was somewhat greater than with material 1 (another material being studied at the same time) but still could be classified as weak. There was no evidence of allergenic action. "
Applicant's summary and conclusion
- Conclusions:
- Tests upon 50 human subjects have indicated that a 15% aqueous solution of this substance is not a primary skin irritant and skin sensitizer.
- Executive summary:
Dowfax 2A1 as a 15% aqueous solution was tested according to the method of Shelanski and Shelanski (proceedings of the Scientific Section of the T Toilet Goods Association, NO. 19, May, 1953). This test involves the application of the test material 5 times a week for 3 weeks to a group of 50 human subjects, 25 males and 25 females for 24 hours. Two to 3 weeks after this routine a challenge application is made to each person at the same site.
Tests upon 50 human subjects have indicated that a 15% aqueous solution of this substance is not a primary irritant, but it caused very slight fatiguing of the skin.
Dowfax 2A1 did not produce evidence of skin sensitization.
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