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EC number: 203-951-1 | CAS number: 112-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Worker-DNEL short-term for the inhalation route (local): Ethylene glycol hexyl ether is not classified for acute inhalation.
Worker-DNEL short-term for the inhalation route (systemic): Ethylene glycol hexyl ether is not classified for acute inhalation.
Worker-DNEL short-term for the dermal route (local): Medium hazard due to classification as skin corrosive Cat 1B – H314: causes severe skin burns and eye damage. ≥ 5% Cat 1B; ≥ 1% but < 5% Cat 2; < 1% not classified.
Worker-DNEL short-term for the dermal route (systemic): The only endpoint assessed in the acute dermal toxicity study is mortality and only limited information on sub-lethal effects can be retrieved from those studies. Therefore, the relevant dose descriptor for short-term exposure via the dermal route is the NOAEL for systemic effects of 222 mg/kg bw/day from a 2-week dermal toxicity study in rabbits. A total assessment factor of 12 to correct for inter- and intra-species differences (according to the ECHA Guidance Document, Chapter R.8) has been applied to derive the DNEL short-term for the dermal route of 18.5 mg/kg bw/day.
Worker-DNEL long-term for the inhalation route (local): No local effects were observed in repeated dose inhalation studies. Therefore, the DNEL for systemic effects is considered to be protective for potential local effects.
Worker-DNEL long-term for the inhalation route (systemic): The relevant dose-descriptor for long-term exposure via the inhalation route is the NOAEC of 41 ppm (245 mg/m3) from a 13-week vapor inhalation study in rats. The only test substance-related effect observed in this study was a dose-dependent increase in liver weights which was not reversed after 4 weeks of recovery in animals exposed to 71 ppm. No effects on red blood cells or histologic changes in the liver or kidney were noted up to the highest concentration tested (71 ppm or 425 mg/m3). Therefore, the NOAEC of 41 ppm has been used as the critical dose descriptor to derive the DNEL. This value has been corrected for exposure duration and a total assessment factor of 10 (according to the ECHA Guidance Document, Chapter R.8) has been applied to correct for intra-species differences and for extrapolating from sub-chronic to chronic exposure. The resulting DNEL long-term for the inhalation route is 3.1 ppm (18.4 mg/m3).
Worker-DNEL long-term for the dermal route (local): Medium hazard due to classification as skin corrosive Cat 1B – H314: causes severe skin burns and eye damage. ≥ 5% Cat 1B; ≥ 1% but < 5% Cat 2; < 1% not classified.
Worker-DNEL long-term for the dermal route (systemic): The relevant dose descriptor for long-term exposure via the dermal route is the NOAEL for systemic effects of 222 mg/kg bw/day from a 2-week dermal toxicity study in rabbits. In this study no overt indications of treatment-related toxicity were observed up to the highest dose level of 444 mg/kg bw/day. However, two females of the high dose group died and the cause of death could not be determined from the evaluations performed in this study. The death may have resulted from stress due to the skin irritation and dosing procedures used. A total assessment factor of 24 to correct for inter- and intra-species differences (according to the ECHA Guidance Document, Chapter R.8) and for exposure duration has been applied to derive the DNEL long-term for the dermal route of 9.3 mg/kg bw/day. The use of a reducedassessment factor of 2 for exposure duration can be justified based on the ECETOC report (2010) on DNEL derivation which concludes that - for chemicals with a short half-life - the extension of the exposure duration to more than 28 days is unlikely to have a significant effect on the NOAEL. For ethylene glycol hexyl ether, a 14-day and a 90-day inhalation study in rats are available. Both studies show similar effects and a similar NOAEC was identified in both studies.As no difference was observed in the NOAEC from sub-acute to sub-chronic study a reduced assessment factor of 2 is considered to be sufficiently protective to correct for exposure duration from a sub-acute study to chronic exposure.
Worker-Eye Exposure: Medium hazard due to classification as Eye Damage Cat 1 – H318: causes serious eye damage. ≥ 3% Cat 1; ≥ 1% but < 3% Cat 2; < 1% not classified.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.9 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 20
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.63 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 48
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.24 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 80
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.49 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- NOAEL
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
General population-DNEL short-term for inhalation route (local): Ethylene glycol hexyl ether is not classified for acute inhalation.
General population-DNEL short-term for inhalation route (systemic): Ethylene glycol hexyl ether is not classified for acute inhalation.
General population-DNEL short-term for dermal route (local): Medium hazard due to classification as skin corrosive Cat 1B – H314: causes severe skin burns and eye damage. ≥ 5% Cat 1B; ≥ 1% but < 5% Cat 2; < 1% not classified.
General population-DNEL short-term for dermal route (systemic): The only endpoint assessed in the acute dermal toxicity studies is mortality and only limited information on sub-lethal effects can be retrieved from those studies. Therefore, the relevant dose descriptor for short-term exposure via the dermal route is the NOAEL for systemic effects of 222 mg/kg bw/day from a 2-week dermal toxicity study in rabbits. A total assessment factor of 24 to correct for inter- and intra-species differences (according to the ECHA Guidance Document, Chapter R.8) has been applied to derive the DNEL short-term for the dermal route of 9.25 mg/kg bw/day.
General population-DNEL short-term for oral route (systemic): The only endpoint assessed in the acute oral toxicity studies is mortality and only limited information on sub-lethal effects can be retrieved from those studies. No repeated dose study via the oral route is available for ethylene glycol hexyl ether. Therefore, the NOAEC of 245 mg/m3 from the 90-day inhalation study in rats has been converted into a systemic dose of 19.4 mg/kg bw and is used as critical dose descriptor to derive the long-term DNEL for oral exposure. A total assessment factor of 40 to correct for inter- and intra-species differences (according to the ECHA Guidance Document, Chapter R.8) has been applied to derive a DNEL short-term for the oral route of 0.49 mg/kg bw/day.
General population-DNEL long-term for inhalation route (local): No local effects were observed in repeated dose inhalation studies. Therefore, the DNEL for systemic effects is considered to be protective for potential local effects.
General population-DNEL long-term for inhalation route (systemic): The relevant dose-descriptor for long-term exposure via the inhalation route is the NOAEC of 41 ppm (245 mg/m3) from a 13-week vapor inhalation study in rats. The only test substance-related effect observed in this study was a dose-dependent increase in liver weights which was not reversed after 4 weeks of recovery in animals exposed to 71 ppm. No effects on red blood cells or histologic changes in the liver or kidney were noted up to the highest concentration tested (71 ppm or 425 mg/m3). Therefore, the NOAEC of 41 ppm has been used as the critical dose descriptor to derive the DNEL. This value has been corrected for exposure duration and a total assessment factor of 20 (according to the ECHA Guidance Document, Chapter R.8) has been applied to correct for intra-species differences and for extrapolating from sub-chronic to chronic exposure. The resulting DNEL long-term for the inhalation route is 0.5 ppm (2.9 mg/m3).
General population-DNEL long-term for dermal route (local): Medium hazard due to classification as skin corrosive Cat 1B – H314: causes severe skin burns and eye damage. ≥ 5% Cat 1B; ≥ 1% but < 5% Cat 2; < 1% not classified.
General population-DNEL long-term for dermal route (systemic): The relevant dose descriptor for long-term exposure via the dermal route is the NOAEL for systemic effects of 222 mg/kg bw/day from a 2-week dermal toxicity study in rabbits. In this study no overt indications of treatment-related toxicity were observed up to the highest dose level of 444 mg/kg bw/day. However, two females of the high dose group died and the cause of death could not be determined from the evaluations performed in this study. The death may have resulted from stress due to the skin irritation and dosing procedures used. A total assessment factor of 48 to correct for inter- and intra-species differences (according to the ECHA Guidance Document, Chapter R.8) and for exposure duration has been applied to derive the DNEL long-term for the dermal route of 4.6 mg/kg bw/day. The use of a reducedassessment factor of 2 for exposure duration can be justified based on the ECETOC report (2010) on DNEL derivation which concludes that - for chemicals with a short half-life - the extension of the exposure duration to more than 28 days is unlikely to have a significant effect on the NOAEL. For ethylene glycol hexyl ether, a 14-day and a 90-day inhalation study in rats are available. Both studies show similar effects and a similar NOAEC was identified in both studies.As no difference was observed in the NOAEC from sub-acute to sub-chronic study a reduced assessment factor of 2 is considered to be sufficiently protective to correct for exposure duration from a sub-acute study to chronic exposure.
General population-DNEL long-term for oral route (systemic): No repeated dose study via the oral route is available for ethylene glycol hexyl ether. Therefore, the NOAEC of 245 mg/m3 from the 90-day inhalation study in rats has been converted into a systemic dose of 19.4 mg/kg bw and is used as critical dose descriptor to derive the long-term DNEL for oral exposure.A total assessment factor of 80 (according to the ECHA Guidance Document, Chapter R.8) has been applied to derive a DNEL long-term for the dermal route of 0.24 mg/kg bw/day.
General population-Eye Exposure: Medium hazard due to classification as Eye Damage Cat 1 – H318: causes serious eye damage. ≥ 3% Cat 1; ≥ 1% but < 3% Cat 2; < 1% not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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