Registration Dossier
Registration Dossier
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EC number: 225-931-1 | CAS number: 5157-75-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dichloromethyloctadecylsilane
- EC Number:
- 225-931-1
- EC Name:
- Dichloromethyloctadecylsilane
- Cas Number:
- 5157-75-5
- Molecular formula:
- C19H40Cl2Si
- IUPAC Name:
- dichloromethyloctadecylsilane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity 90,9%
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Remarks:
- Highest dose: as supplied (no vehicle); dilution with corn oil
- Doses:
- 2000 mg/kg b.w.
200 mg/kg b.w. - No. of animals per sex per dose:
- 3
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Silan ODM has to be classified as harmful (200 mg/kg < LD50 < 2000 mg/kg).
The oral L050 value for Silan ODM in CD® rats was ranked within the LD50 range of
200 - 2000 mg/kg body weight. - Executive summary:
Silan ODM was administered orally by gavage to three male CD® rats at 2000 mg/kg body weight and, in addition, to six CD® rats (3 / sex) at 200 mg/kg body weight. Animals were subjected to daily observations and weekly determinations of body weight. Macroscopic examination was performed immediately after premature death or after terminal sacrifice (test day 15). 2000 mg/kg b.w. resulted in the death within 4 days of all male animals. 2000 mg/kg resulted following signs of systemic toxicity: reduced motility, ataxia, reduced muscle tone, dyspnoea, myosis. None of the six CD® rats employed at 200 mg/kg b.w. died. All animals at 200 mg/kg b.w. showed no signs of systemic toxicity. All surviving animals gained the expected body weight within the study period. No abnormalities were found at macroscopic post mortem examination of the animals. The oral LD50 value for Silan ODM in CD® rats was ranked within the LD50 range of 200 - 2000 mg/kg body weight.
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