Registration Dossier
Registration Dossier
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EC number: 226-420-6 | CAS number: 5397-31-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Range finding data: only results are available, no study details are given
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method as described in "The Place of the Range Finding Test in the Industrial Toxicology Laboratory" - H.F. Smyth Jr. and C.P. Carpenter; J. Indust. Hyg. & Toxicol. 26: 269, 1944: Groups of six male albino rats are exposed to a flowing stream of air substantially saturated with vapors of the test material, prepared by passing it through a fritted disc bubbler at room temperature for periods of time falling in a geometric series with a constant ratio of two, up to eight hours as a maximum. This practice is repeated on new groups of rats until we find an exposure time which kills all of six, and another time which kills none of six, within two weeks after inhalation.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-(2-ethylhexyloxy)propylamine
- EC Number:
- 226-420-6
- EC Name:
- 3-(2-ethylhexyloxy)propylamine
- Cas Number:
- 5397-31-9
- Molecular formula:
- C11H25NO
- IUPAC Name:
- 3-[(2-ethylhexyl)oxy]propan-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- saturated vapour
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: not specified
- Effect level:
- other: not specified
- Based on:
- not specified
- Exp. duration:
- 8 h
- Remarks on result:
- other: no concentration and no quantitative result reported
- Mortality:
- No animal died after 8 hour inhalation of saturated vapour of the test subsance.
Any other information on results incl. tables
no data on concentrations, findings or mortality is given
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
