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EC number: 203-984-1 | CAS number: 112-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1986-11-06 to 1986-12-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was well conducted and document and does appear to have largely followed OECD guideline 403 recommendations, but the specifics of the followed HUK protocol P2885d was not provided..
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: HUK protocol number P2885d
- Deviations:
- yes
- Remarks:
- Animals were exposed to test article for 4.5 hours as a result of a generator stoppage during the first half hour. Oxygen concentration was recorded at 30 minute intervals.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Octane-1-thiol (CAS # 111-88-6)
- IUPAC Name:
- Octane-1-thiol (CAS # 111-88-6)
- Details on test material:
- - Name of test material (as cited in study report): octane-1-thiol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Ltd. Margate.
- Age at study initiation: 6 to 8 weeks
- Weight at study initiation: 180 to 200
- Housing: grid-floor cages by sex
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 25
- Humidity (%): 40 to 70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- head only
- Vehicle:
- other: unchanged (no vehicle)
- Duration of exposure:
- ca. 4.5 h
- Concentrations:
- 518 ppm (3.10 mg/L)
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.1 mg/L air
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 518 ppm
- Mortality:
- There were no deaths during the course of the study.
- Clinical signs:
- other: Clinical signs observed were ataxia, lethargy, salivation, lachrymation, and piloerection on the day of exposure. Piloerection was also noted on the following day. There were no treatment-related macroscopic or microscopic changes evident.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Octane-1-thiol vapour was not acutely toxic to rats following inhalation for 4.5 hours at a concentration of 518 ppm (3.1 mg/L) Criteria used for interpretation of results: EU
- Conclusions:
- This study reported no toxic effects in rats exposed to octane-1-thiol by head only inhalation.
- Executive summary:
In an acute inhalation toxicity study, young adult Sprague-Dawley rats (5/sex) were exposed (head only), to 3.10 mg/L octane-1-thiol for 4.5 hours. Animals then were observed for 14 days.
There were no treatment-related macroscopic or microscopic changes evident. Clinical signs observed during the study were ataxia, lethargy, salivation, lachrymation, and piloerection on the day of exposure. Piloerection was also noted on the following day. The inhalation LC50 was determined to be greater than 3.10 mg/L in males and females.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it was well conducted and document and does appear to have largely followed OECD guideline 403 recommendations, but the specifics of the followed HUK protocol P2885d was not provided.
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