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Diss Factsheets
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EC number: 480-340-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NOAEL (P/F1, reproductive) = 30 mg/kg-day (nominal)
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data are available for the assessment of the toxicity potential of the substance on fertility. Available data from literature for the dissociation substances are used for the assessement of the toxicity of the substance. Justification for Read Across is given in Section 13 of IUCLID.
Effects on developmental toxicity
Description of key information
NOAEL (rats) = 30 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data are available for the assessment of the toxicity potential of the substance on development. Available data from literature for the dissociation substances are used for the assessement of the toxicity of the substance. Justification for Read Across is given in Section 13 of IUCLID.
Justification for classification or non-classification
For the assessment of classification for reproductive toxicity of the substance, data on the dissociation substances were evalauted.
Exposure to perchlorate up to 30 mg/kg bw/day (maximum concentration tested) did not produce any reproductive effects to P1 and F1 generation rats. In the two-generation study, effects on lactation could be evaluated; it is noticable that the lactation index in the exposure groups (0.001 - 30.0 mg/kg bw-day) was comparable to the one of control group. Furthermore, viability index and litter size were not affected by perchlorate exposure while pup weights were even increased in some cases. Triethanolamine did not produce any reproductive or developmental effects up to the tested concentration (1125 mg/kg bw/day) as assessed in a post-natal mouse screening test and does not cause any developmental effects according to a developmental toxicity study (rats and rabbits, dermal) and a pre-, per- and postnatal study (rats, oral).
Perchlorate did not induce any developmental effects to fetus when administered in pregnant rabbits at doses as high as 100 mg/kg/day in the drinking water. No fetal alterations, either malformations or variations, were attributable to the perchlorate administration in rats. However, the average number of ossification sites per litter for sternal centers and for forelimb phalanges were significantly reduced in the 30.0 mg/kg-day exposure group, these reductions were considered reversible developmental delays and were not considered teratologically important because there were no skeletal malformations of the sternum or phalanges at this exposure level. However, based on these findings the NOAEL for developmental toxicity was found to be 1.0 mg/kg bw/day based on developmental delays in ossification which occurred in the 30.0 mg/kg-day group. Notwithstanding the effects of the substance on the number of ossification sites, it is worth saying that no adverse effects on development occured at levels that did not cause maternal toxicity. It could be suggested that these adverse effects were influenced by the maternal toxicity which was noted in even lower doses.
Based on the data of perchlorate and triethanolamine, the substance is not classified for reproductive toxicity. This is in accordance with eMSCA conclusion for the toxicity to reproduction (fertility and developmental) of triethanolamine, as stated in the Substance Evaluation Report- CoRAP (version 1.1, dated August 2015) and with eMSCA conclusion for reproductive toxicity of perchlorate as stated in the Substance Evaluation Conclusion Document- CoRAP (dated August 10th 2016).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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