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EC number: 283-740-9 | CAS number: 84712-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-06-24 to 2016-11-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 of 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 05/07/2016; Date of issue: 28/10/2016
- Type of method:
- flask method
- Key result
- Water solubility:
- 0 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- ca. 6.3 - ca. 6.9
- Key result
- Water solubility:
- ca. 0 - ca. 0 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- ca. 6.3 - ca. 6.9
- Remarks on result:
- other: Range of values
- Details on results:
- On completion of the equilibration period, the samples were clear and colourless with excess test item present within the test vessels. The solutions were decanted, avoiding excess test item prior to centrifugation. After centrifugation, the supernatant was taken for analysis.
The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1x10-2 g/L. However, due to the physical nature of the test item, it was not possible to use this method; experience has shown that liquid test items coated onto glass beads cause these beads to adhere together forming a plug within the column and thus preventing water circulation.
The method of analysis showed some variability likely due to the low working level and the accuracy of the method at these low levels. Due to this, not all of the samples fell within ± 15% of the mean as specified in the test guidelines. There was however no obvious issues with the chromatography (e.g. contamination) which would account for the variability, and therefore all of the sample results were included in the overall result. The test item was deemed to have reached saturation.
The test item is a UVCB/multi-constituent compound, therefore all peaks were analysed as a group to determine the water solubility of the test item as a whole and not the individual constituents due to the limits of the chromatographic method. - Conclusions:
- A water solubility value of 3.08 x 10-5 g/L at 20.0 ± 0.5 °C was determined for the substance using a relevant test method and in compliance with GLP. The result is considered to be reliable.
- Executive summary:
The water solubility of the test item has been determined to be 3.08 x 10-5 g/L of solution at 20.0 ± 0.5 °C.
Reference
Preliminary Test:
The preliminary estimate of water solubility was 5.0 x 10-4 g/L at 20.0°C.
Main test:
Typical chromatography is presented in the Appendix 1 (attached).
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean peakarea |
Standard 12.7 |
2.8497 x 106 |
Standard 12.9 |
3.1105 x 106 |
Blank |
2.3957 x 104 |
Sample 1A |
2.4516 x 105 |
Sample 1B |
1.8679 x 105 |
Sample 2A |
1.8498 x 105 |
Sample 2B |
1.4128 x 105 |
Standard 12.8 |
2.5772 x 106 |
Standard 13.3 |
2.50186 x 106 |
Sample 3A |
1.1757 x 105 |
Sample 3B |
1.4896 x 105 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample number |
Time shaken at ~ 30 ºC (hours) |
Time equilibrated at 20 ºC (hours) |
Concentration (g/L) |
Average Concentration (g/L) |
Solution pH |
1A |
24 |
24 |
4.22 x 10-5 |
3.71 x 10-5 |
6.3 |
1B |
24 |
24 |
3.21 x 10-5 |
||
2A |
48 |
24 |
3.18 x 10-5 |
2.81 x 10-5 |
6.9 |
2B |
48 |
24 |
2.43 x 10-5 |
||
3A |
72 |
24 |
2.41 x 10-5 |
2.73 x 10-5 |
6.3 |
3B |
72 |
24 |
3.05 x 10-5 |
Mean concentration : 3.08
x 10-5 g/L at 20.0 ± 0.5 ºC
Range : 2.73 x
10-5 to 3.71 x 10-5 g/L
Standard Deviation : 5.47
x 10-6
Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration ranges of 0.5 to 15 mg/L and 5.0 to 20.0 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 and 0.998 being obtained respectively.
Recovery of analysis of the sample procedure was assessed and proved adequate for the test, see following table for details.
Recovery data is shown in the following table:
Nominal concentration (mg/L) |
Recovery range (%) |
Mean recovery (%) |
0.632 |
81.3 to 85.9 |
83.9 |
0.0506 |
69.8 to 80.2 |
75.0 |
Concentrations have not been corrected for recovery of analysis.
Description of key information
Water solubility: 3.08 x 10-5 g/L at 20.0 ± 0.5 °C (OECD 105)
Key value for chemical safety assessment
- Water solubility:
- 0 g/L
- at the temperature of:
- 20 °C
Additional information
Water solubility values in the range 2.73E-05 to 3.71E-05 g/L and a mean water solubility value of 3.08E-5 g/L at 20.0 ± 0.5°C were determined for the whole substance in a study conducted in accordance with OECD Test Guideline 105 and in compliance with GLP. The result is considered to be reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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