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Diss Factsheets
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EC number: 203-397-0 | CAS number: 106-43-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: short description but provides sufficient information to be taken into account
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effects of p-chlorotoluene on rat lung and liver benzo(a)pyrene metabolism and microsomal membrane structure and function
- Author:
- Zewdie T, Silverman DM, Schatz RA
- Year:
- 1 997
- Bibliographic source:
- J Toxicol Environm Health 50, 159-172
- Reference Type:
- publication
- Title:
- The influence of time and dose on the development of p-chlorotoluene (PCT) induced changes in rat liver and lung cytochrome P450 system and Benzo(a)pyrene(BaP) metablolism
- Author:
- Zewdie T, Silverman D, Schatz R
- Year:
- 1 991
- Bibliographic source:
- The Toxicologist 11(1), 319 (abstr.)
Materials and methods
- Objective of study:
- distribution
- Principles of method if other than guideline:
- Male Sprague-Dawley rats weighing 200-225 g (Charles River Breeding Labs, Willmington, MA) were maintained on tap water and standard lab feed ad libitum in a 12-h light-dark cycle for 3 d prior to treatment. PCT, 0.5, 1, or 1.5 g/kg, was administered to rats in preservative-free soybean oil (4 ml/kg, ip). Controls were given preservative- free soybean oil only (4 ml/kg, ip). Animals were killed by cervical dislocation 1, 4, or 12 h after solvent injection. Lungs and livers were perfused in situ with 0.9% saline (25°C) until lungs were pink to white in color. All tissues were stored at -80°C for a maximum of 2 wk.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chlorotoluene
- EC Number:
- 203-397-0
- EC Name:
- 4-chlorotoluene
- Cas Number:
- 106-43-4
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 4-chlorotoluene
- Details on test material:
- p-chlorotoluene, purity: 98 %
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- soya oil
- Duration and frequency of treatment / exposure:
- single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 0, 500, 1000, 1500 mg/kg bw in soybean oil
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- no data
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- no data
Any other information on results incl. tables
When PCT (1 g/kg, ip) was given to rats, blood and lung levels rose rapidly at 1 h and, for the time points tested, reached near maximal values at 4 h. Liver levels reached maximum levels at 1 h and started to decline at 4 h. Lowest solvent tissue levels were observed at 12 h.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
Male Sprague-Dawley rats weighing 200-225 g were maintained on tap water and standard lab feed ad libitum in a 12-h light-dark cycle for 3 d prior to treatment. PCT, 0.5, 1, or 1.5 g/kg, was administered to rats in preservative-free soybean oil (4 ml/kg, ip). Animals were killed by cervical dislocation 1, 4, or 12 h after solvent injection. Lungs and livers were perfused in situ with 0.9% saline (25°C) until lungs were pink to white in colorand, PCT concentrationsin lungs and livers were measured.
When PCT (1 g/kg, ip) was given to rats, blood and lung levels rose rapidly at 1 h and, for the time points tested, reached near maximal values at 4 h.Liver levels reached maximum levels at 1 h and started to decline at 4 h.Lowest solvent tissue levels were observed at 12 h.
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