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EC number: 445-620-6 | CAS number: 39318-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30/06/2003-04/07/2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- ISO 7346-1 (Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] - Part 1: Static Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Lithium Potassium Titanium Oxide
- EC Number:
- 445-620-6
- Cas Number:
- 39318-30-4
- Molecular formula:
- Hill Empirical formula: K(0.5-0.7) Li(0.27) Ti(1.73) O(3.8-3.95) CAS Empirical formula: K(0.5-0.7) Li(0.27) Ti(1.73) O(3.8-3.95)
- IUPAC Name:
- Lithium Potassium Titanium Oxide
- Details on test material:
- - Name of test material (as cited in study report): TERRACESS L
- Substance type: white powder
- Physical state: solid
- Lot/batch No.: 2D79A
- Expiration date of the lot/batch: 11 April 2004
- Storage condition of test material: At room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 5 µm filtered solution prepared from a 100 mg/l suspension and the control.
- Sampling method: 20 ml from the approximate centre of the test vessels
- Sample storage conditions before analysis: stored in a deep-freeze until shipment to Solvias AG, Basel, Switzerland
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: None.
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A 5 µm filtered solution prepared at a loading rate of 100 mg/l (filtered after 3 days of stirring) and dilutions containing 0.1, 1.0 and 10% of the filtrate.
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Strain: Teleostei, Cyprinidae
- Source: Zodiac, proefacc, "De Haar Vissen", L.U. Wageningen, the Netherlands.
- Age at study initiation (mean and range, SD): not reported
- Length at study initiation (length definition, mean, range and SD): 2.0 ± 0.2 cm
- Weight at study initiation (mean and range, SD): 0.21 ± 0.04 g
- Method of breeding: F1 from a single parent-pair bred in UV-treated water.
- Feeding during test: No feeding from 48 hours prior to the test and during the total test period.
ACCLIMATION
- Acclimation period: At least 12 days after delivery
- Acclimation conditions (same as test or not): yes
- Type and amount of food: Trouvit
- Feeding frequency: Daily
- Health during acclimation (any mortality observed): In the batch of fish used for the test, mortality during the seven days prior to the start of the test was less than 5%.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- Blank control: 20.3 (day 0) to 20.9 (day 4)
0.1 % filtrate: 20.3 (day 0)
1 % filtrate: 20.4 (day 0)
10% filtrate: 20.7 (day 0)
100 % filtrate: 20.6 (day 0) to 21.0 (day 4)
Test groups represent percentages of a 5 µm filtered solution prepared at a nominal loading of 100 mg/l. - pH:
- Blank control: 7.2-7.9
100 % filtrate: 7.1-8.3 - Dissolved oxygen:
- Blank control: 6.7-8.8
100 % filtrate: 6.3-8.8 - Nominal and measured concentrations:
- The nominal concentrations of Terracess L were prepared as follows: A 5 µm filtered solution prepared at a loading rate of 100 mg/l (3 days stirring) and dilutions containing 0.1, 1.0 and 10% of the filtrate.
The blank-filtrate: Test medium without test substance or other additives (0 mg/l).
Analysis of the samples taken from the 5 µm filtrate prepared at a loading rate of 100 mg/l showed that measured concentrations based on Lithium and Titanium were below the detection limit of the analytical method, i.e. below 0.1 mg/l. The Potassium concentration could be measured and remained stable at 3 mg/l during the 96-hour test period.
Extrapolating this concentration to the concentration of the test substance TERRACESS L resulted in a concentration of 13 mg/l (using the formula: K concentration analysed / 0.76* M K )* M TERRACESS L). - Details on test conditions:
- TEST SYSTEM
- Test vessel: 6.5 litres, all-glass.
- Aeration: The test media were not aerated during the test.
- Type of flow-through: static
- No. of organisms per vessel: 3 ( for the 0.1, 1 and 10 % of the filtrate) and 7 ( for the blank-control and 100 mg/L filtered through 5 um filter)
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: Control and 100 mg/l filtrate: 0.37 g fish/litre, i.e. 7 fish per 4 litres of test medium; Dilutions: 0.16 g fish/litre, i.e. 3 fish per 4 litres of test medium.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ISO-medium, formulated using Milli-Ro water (tap-water purified by reverse osmosis; Millipore Corp., Bedford, Mass., USA) with the following composition:
CaCl2.2H2O 293.8 mg/l
MgSO4.7H2O 123.3 mg/l
NaHCO3 64.8 mg/l
KCl 5.8 mg/l
- Culture medium different from test medium: no
- Intervals of water quality measurement: pH, nitrate and nitrite concentration and ammonia concentration: once a week. Temperature: every day.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours photoperiod daily
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Justification for using less concentrations than requested by guideline: not applicable
- Range finding study: no
- Test concentrations: Test groups (0.1; 1; 10 and 100) represent percentages of a 5 µm filtered solution prepared at a nominal loading of 100 mg/l (filtrate).
- Results used to determine the conditions for the definitive study: No mortality or clinical effects observed in the limit/range finding test. - Reference substance (positive control):
- yes
- Remarks:
- pentachlorophenol (PCP)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 3 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- element
- Remarks:
- Potassium
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: (> WSL)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 17.62 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- Terracess L
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: (> WSL)
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: no
- Other adverse effects control: no - Results with reference substance (positive control):
- - Results with reference substance valid? yes
Under the conditions of the present test PENTACHLOROPHENOL induced no lethal effects in carp at or below 0.15 mg/l. The 96h-LC50 for carp exposed to PCP was 0.21 mg/l (95 % confidence interval between 0.19 and 0.27 mg/l). The 24h-LC50 was 0.24 mg/l (95% confidence interval between 0.21 and 0.30 mg/l), and remained unchanged until 72h. The range of the 96h-LC50 for carp is generally between 0.10 and 0.46 mg/l based on historical data of reference tests performed approximately every 3 months from April 1988 until the end 2000, and annually since then. The response observed in carp originating from the present batch falls within this range.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present test TERRACESS L induced no visible effects in carp at or below a 5 µm filtered solution prepared at a loading rate of 100 mg/l.
The 95-h LC50 was above WSL .
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