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EC number: 603-525-9 | CAS number: 131860-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-03-12 to 1992-04-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Summary report signed by the study director of the original GLP study, plus one internal reviewer. The toxicological information contained in the report is derived from studies which fulfil the requirements of good laboratory practice. The report format does not give all informations required by the guideline: Some experimental details and individual data are not provided. The study was conducted according to a method similar to OECD Guidelines with some deviations: exposure was only for 1 hour; maximum concentration tested was <5mg/L.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- not stated in report
- Deviations:
- yes
- Remarks:
- Exposure time 1 hour, maximum concentration tested 1.89 mg/liter, no limit test
- GLP compliance:
- yes
- Remarks:
- Confirmed by study director
- Test type:
- other: acute method, 1-hr exposure
- Limit test:
- no
Test material
- Reference substance name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- IUPAC Name:
- Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
- Reference substance name:
- 603-525-9
- EC Number:
- 603-525-9
- Cas Number:
- 131860-97-4
- Molecular formula:
- C15H13ClN2O4
- IUPAC Name:
- 603-525-9
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Determination of atmospheric concentration and mass median aerodynamic diameter, no methods specified
- Duration of exposure:
- 1 h
- Remarks on duration:
- no rationale given
- Concentrations:
- 1.89 mg/liter, +/- 0.11 mg/liter (SD)
mass median aerodynamic diameter 4.86 micrometer, geometric standard deviation 2.33 - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Observation period 14 days
Post-mortem examination
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 1.89 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- None
- Clinical signs:
- other: No adverse clinical effects Slight irritant effect in two males immediately after exposure General recovery by day 2, but slight piloerection in some animals throughout the 14-day observation period
- Body weight:
- No data
- Gross pathology:
- No treatment-related changes
Applicant's summary and conclusion
- Interpretation of results:
- other: Not conclusive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- While the full study report is not available, the results are sufficiently detailed and unambiguous. The 1-hour inhalation LC50 is >1890 mg/m3.
For aerosols, which are normally not secondarily exhaled, an approximate extrapolation to the usual 4-hour exposure can be based on Haber's rule (Miller FJ, Schlosser PM & Janszen DB, Toxicology, 2000, 149, 22-34). This calculation results in a four- hour inhalation LC50 >470 mg/m3.
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