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Diss Factsheets
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EC number: 700-208-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Study period:
- 2014-02-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: expert statement
Data source
Reference
- Reference Type:
- other: theoretical assessment
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
- Objective of study:
- toxicokinetics
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide AND N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide
- EC Number:
- 700-208-8
- Molecular formula:
- C7H11N3O
- IUPAC Name:
- Reaction mass of N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide AND N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no data
Since no toxicokinetic studies are available for MPA the assessment of the toxicokinetic behavior is based on the physico-chemical properties of the substance.
a) Absorption
Oral absorption:
The very water soluble substance MPA will readily dissolve in the gastrointestinal fluids.
Its relatively low molecular weight of 153 g/Mol, the relative high water solubility and the moderate log Pow of 0.76 favors its absorption in the gastrointestinal tract by passive diffusion. However, since the molecular weight is below 200 g/Mol the substance may also be taken up by passing through aqueous pores of the epithelial barrier.
Therefore, for evaluation of MPA in the chemical safety assessment, the oral absorption of MPA is set at 100 %.
The results of the toxicity studies with MPA do not provide any reason to deviate from this proposed degree of oral absorption.
Dermal absorption:
Making use of the data for molecular weight and the log Pow the skin permeability can be calculated according to the model of Potts and Guy (Potts, R. O., and Guy, R. H.: “Predicting skin permeability” Pharm. Res. 9, 663-669 (1992)).
The model estimates the figure for the skin permeation coefficient kp, which is a measure of the conductance of skin to a particular chemical substance from a particular vehicle. The kp was calculated to be 7.33E-04 cm/hour, therefore a relevant skin penetration may be possible for the substance MPA.
According to the criteria given in the ECHA guidance document “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance”, November 2012 (version 1.1) 10 % dermal absorption will be considered in case MW > 500 g/Mol and log Pow <-1 and >4, otherwise 100 % dermal absorption is assumed.
In consequence, 100 % dermal absorption is proposed for MPA.
Respiratory absorption:
Deposition pattern for dusts depends on the particle sizes of the substance to be inhaled. In general, particles having an aerodynamic diameter of greater than 10 µm are deposited in the nasopharyngeal region. Particles smaller than 10 µm are capable for reaching the alveolar region of the respiratory tract.
Since the measurement of the particle size distribution of MPA indicates no particles smaller than 10 µm, deposition of MPA after inhalation predominately takes place in the nasopharyngeal region.
After deposition water soluble particles of MPA may readily diffuse/dissolve into the mucus lining of the nasopharyngeal region and may then be dermally absorbed.
b) Distribution
After absorption MPA is expected to distribute easily throughout the body based on its low molecular weight, the log Pow > 0 (some lipophilicity) and the high water solubility.
Since the log Pow is only slightly above zero, MPA can also distribute into cells to a minor extent so that the intracellular concentration may be higher than the extracellular concentration, particularly in fatty tissues.
Since the log Pow of MPA is < 4 the substance is not expected to accumulate within the body.
c) Metabolism
Once absorbed, the mammalian organism may metabolize the substance MPA by hydroxylation of appropriate carbon and nitrogen atoms which may be followed by conjugation. - Executive summary:
Since no toxicokinetic studies are available for MPA the assessment of the toxicokinetic behavior is based on the physico-chemical properties of the substance.
a) Absorption
Oral absorption:
The very water soluble substance MPA will readily dissolve in the gastrointestinal fluids.
Its relatively low molecular weight of 153 g/Mol, the relative high water solubility and the moderate log Pow of 0.76 favors its absorption in the gastrointestinal tract by passive diffusion. However, since the molecular weight is below 200 g/Mol the substance may also be taken up by passing through aqueous pores of the epithelial barrier.
Therefore, for evaluation of MPA in the chemical safety assessment, the oral absorption of MPA is set at 100 %.
The results of the toxicity studies with MPA do not provide any reason to deviate from this proposed degree of oral absorption.
Dermal absorption:
The maximum absorbed quantity into the skin was determined as 2.44 µg.cm-2for MPA after 24 hours contact with the skin. This corresponds to 0.21 % of the applied dose MPA.
Based on these results, it can be stated that there will be a negligible transport of MPA into or through human skin.
Respiratory absorption:
Deposition pattern for dusts depends on the particle sizes of the substance to be inhaled. In general, particles having an aerodynamic diameter of greater than 10 µm are deposited in the nasopharyngeal region. Particles smaller than 10 µm are capable for reaching the alveolar region of the respiratory tract.
Since the measurement of the particle size distribution of MPA indicates no particles smaller than 10 µm, deposition of MPA after inhalation predominately takes place in the nasopharyngeal region.
After deposition water soluble particles of MPA may readily diffuse/dissolve into the mucus lining of the nasopharyngeal region and may then be dermally absorbed.
b) Distribution
After absorption MPA is expected to distribute easily throughout the body based on its low molecular weight, the log Pow > 0 (some lipophilicity) and the high water solubility.
Since the log Pow is only slightly above zero, MPA can also distribute into cells to a minor extent so that the intracellular concentration may be higher than the extracellular concentration, particularly in fatty tissues.
Since the log Pow of MPA is < 4 the substance is not expected to accumulate within the body.
c) Metabolism
Once absorbed, the mammalian organism may metabolize the substance MPA by hydroxylation of appropriate carbon and nitrogen atoms which may be followed by conjugation.
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