Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

No data on the acute toxicity of NbC to aquatic microorganisms are available. Thus, data on the respiration inhibition of NbCl5 were used in a read-across approach.  An activated sludge respiration inhibition test according to OECD 209 and under GLP resulted in an EC50 > 1000 mg/L and an NOEC ≥ 1000 mg/L.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information

Available data from niobium pentachloride are appropriate to be used for the read-across approach. Due to lower water solubility for niobium carbide compared to niobium pentachloride the resulting toxicity is also expected to be lower. Hence, the read across to the substance niobium pentachloride is sufficiently protective. An activated sludge respiration inhibition test according to OECD 209 resulted in an EC50 > 1000 mg/L and an NOEC ≥ 1000 mg/L. The test substance was directly added to the test vessels at a nominal concentration of 1000 mg/L. The pH in the test vessels was adjusted by means of 5n NaOH. After 180 min, inhibition of less than 20% was observed at a concentration of 1000 mg/L (-5 to 18% inhibition). According to a STUDENT t-test, the respiration rates in the test vessels were not significant lower than the respiration rate of the controls.