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EC number: 240-012-5 | CAS number: 15876-58-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.09.2016 - 23.09.2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Test according to OECD 201.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Principles of method if other than guideline:
- Freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)-3,4,5,6-tetrachlorobenzoate) according to OECD Guideline 201.
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material: Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)-3,4,5,6-tetrachlorobenzoate)
- Molecular formula: C20H4Br4Cl4O5.2/3Al
- Physical state: Solid - Analytical monitoring:
- no
- Details on sampling:
- No data available
- Vehicle:
- no
- Details on test solutions:
- The stock solution (100 mg/L) was prepared by dissolving dark red powder in OECD growth medium. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture.
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM- Common name: Desmodesmus subspicatus
- Strain: 86.81 SAG
- Source (laboratory, culture collection): Institute of botany of the ASCR
- Initial biomass concentration: 5x10(3) cells /ml - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- ±1 hour
- Post exposure observation period:
- No data
- Hardness:
- no data
- Test temperature:
- 23±2°C
- pH:
- Test: 7.7 (changed to 8.0 during test)Control: 8.2 (changed to 7.5 during test)
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Conductivity:
- no data
- Nominal and measured concentrations:
- 0, 5, 10, 20, 40 and 80 mg/L
- Details on test conditions:
- TEST SYSTEM- Test vessel: 50 ml Glass vessel
- Type (delete if not applicable): closed (with air permeable stopper)
- Sample volume: 7.5 ml- Initial cells density: 5x10(3) cells/ml
- No. of vessels per concentration (replicates): 3
GROWTH MEDIUM
- Standard medium used: yes
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: Continuous
- Light intensity and quality: 6000-8000 lx
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: microscope with counting chamber Cyrus I or electronic particle counter.
- Other: ErC50 was calculated using non-linear regression by the software Prism 4.0 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (K2Cr2O7)
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL: 19,5 - 32.1
- Details on results:
- No data available
- Results with reference substance (positive control):
- Results with reference substance valid- EC50: 0.69 mg/L
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 for CAS 15876-58-1 was 25.0 mg/L (95% C.I.: 19.5-32.1 mg/L) after 72 hours of exposure.
- Executive summary:
A freshwater algal growth inhibition exposure assessment was used to test how a range of concentrations of CAS 15876-58-1 exerts different degrees of toxic effects on the growth of Desmodesmus subspicatusunder otherwise identical test conditions. The test was performed in close resemblance to OECD guideline 201 by ABITEC in Prague, Crez Republic. The standardized protocol used to obtain the herein described results was by the testing laboratory referred to as “CSN EN ISO 8692”. The 72 hours EC50 was by the testing laboratory defined as the concentration estimated to inhibit 50 per cent of the algae cell growth compared to unexposed cells after 72 hours of exposure. The nominal concentrations used for the exposure assessment were as follows: 5, 10, 20, 40 and 80 mg/L. The positive control/reference substance used in the tested showed an expected result and gave a EC50 that corresponded to previous exposures with this chemical in Desmodesmus subspicatus. After exposure was the EC50 calculated using nonlinear regression by the software Prism 4.0 (Graphpad Software, Inc., San Diego CA). In conclusion, the EC50 for CAS 15876-58-1 was 25.0 mg/L (95% C.I.: 19.5-32.1 mg/L) after 72 hours of exposure.
Based on the EC50, Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] was consider as toxic and can be consider as classified in aquatic chronic 3 as per CLP classification criteria.
Reference
Description of key information
A freshwater algal growth inhibition exposure assessment was used to test how a range of concentrations of CAS 15876-58-1 exerts different degrees of toxic effects on the growth ofDesmodesmus subspicatusunder otherwise identical test conditions. The test was performed in close resemblance to OECD guideline 201 by ABITEC in Prague, Crez Republic. The standardized protocol used to obtain the herein described results was by the testing laboratory referred to as “CSN EN ISO 8692”. The 72 hours EC50 was by the testing laboratory defined as the concentration estimated to inhibit 50 per cent of the algae cell growth compared to unexposed cells after 72 hours of exposure. The nominal concentrations used for the exposure assessment were as follows: 5, 10, 20, 40 and 80 mg/L. The positive control/reference substance used in the tested showed an expected result and gave a EC50 that corresponded to previous exposures with this chemical inDesmodesmus subspicatus. After exposure was the EC50 calculated using nonlinear regression by the software Prism 4.0 (Graphpad Software, Inc., San Diego CA). In conclusion, the EC50 for CAS 15876-58-1 was 25.0 mg/L (95% C.I.: 19.5-32.1 mg/L) after 72 hours of exposure.
Based on the EC50, Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] was consider as toxic and can be consider as classified in aquatic chronic 3 as per CLP classification criteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 25 mg/L
Additional information
A freshwater algal growth inhibition exposure assessment was used to test how a range of concentrations of CAS 15876-58-1 exerts different degrees of toxic effects on the growth ofDesmodesmus subspicatusunder otherwise identical test conditions. The test was performed in close resemblance to OECD guideline 201 by ABITEC in Prague, Crez Republic. The standardized protocol used to obtain the herein described results was by the testing laboratory referred to as “CSN EN ISO 8692”. The 72 hours EC50 was by the testing laboratory defined as the concentration estimated to inhibit 50 per cent of the algae cell growth compared to unexposed cells after 72 hours of exposure. The nominal concentrations used for the exposure assessment were as follows: 5, 10, 20, 40 and 80 mg/L. The positive control/reference substance used in the tested showed an expected result and gave a EC50 that corresponded to previous exposures with this chemical inDesmodesmus subspicatus. After exposure was the EC50 calculated using nonlinear regression by the software Prism 4.0 (Graphpad Software, Inc., San Diego CA). In conclusion, the EC50 for CAS 15876-58-1 was 25.0 mg/L (95% C.I.: 19.5-32.1 mg/L) after 72 hours of exposure.
Based on the EC50, Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] was consider as toxic and can be consider as classified in aquatic chronic 3 as per CLP classification criteria.
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