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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1973
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Acute toxicity data are tabulated in a continuing program to predict potential acute hazards to health of accidental human contact. Table only, no further information.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974
Report date:
1973

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: H.F. Smyth et al., 1962, Range finding toxicity data: List VI, Am. Ind. Hyg. J., 23, 95-107
Deviations:
not specified
Principles of method if other than guideline:
no data
GLP compliance:
no
Remarks:
performed before GLP guidelines
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
But-3-en-3-olide
EC Number:
211-617-1
EC Name:
But-3-en-3-olide
Cas Number:
674-82-8
Molecular formula:
C4H4O2
IUPAC Name:
4-methylideneoxetan-2-one
Constituent 2
Reference substance name:
Keten dimer
IUPAC Name:
Keten dimer
Details on test material:
no data

Test animals

Species:
rat
Strain:
other: Carworth-Wistar male rats
Sex:
male
Details on test animals or test system and environmental conditions:
The rats were 4 - 5 weeks of age and 90 - 120 g in weight. They were reared in the colony of the Mellon Institute in Pittsburgh and maintained from time of weaning on Rockland rat diet

Administration / exposure

Route of administration:
other: gastric intubation
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no data
Doses:
The dosages are arranged in a logarithmic series differing by a facto of two
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
no data
Statistics:
Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
613 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Any other information on results incl. tables

95% confidence limits 317-1170 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the measured LD50 value of 0.56 mL/kg bw (corresponding to 613 mg/kg bw) the substance is to be classified as harmful, Xn, R22;
H302 - harmful if swallowed.
Executive summary:

According to the measured LD50 value of 613 mg/kg bw the substance is to be classified as harmful, Xn, R22; H302 - harmful if swallowed.