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Diss Factsheets
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EC number: 211-617-1 | CAS number: 674-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral:
- male rats, LD50: 613 mg/kg bw (limited data only)
- rats, LD50: 540 mg/kg bw (limited data only)
Inhalation:
- male/female rats, LC50: 0.94 mg/L
- male rats, LC50: 0.82 mg/L
- female rats, LC50: 1.01 mg/L
Dermal:
- male rabbits, LD50: 3100 mg/kg bw (limited data only)
- male rabbits, LD50: 6730 mg/kg bw (limited data only)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 540 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 820 mg/m³ air
Additional information
Except for acute inhalation toxicity only very restricted information is available in rats and rabbits for the acute toxicity of Diketene. The lowest oral LD50determined was 540 mg/kg bw rats. The LC50 (4-hour) for Diketene for male rats as most sensitive species was established at 0.82 mg /L and in two unreliable publications a dermal LD50 of 3100 mg/kg bw/d in rabbits is reported. All results are shown in the “Short description of key information” field
Justification for classification or non-classification
Due to the findings described above (LD50 oral in rats 540 mg/kg bw, LC50 inhalation in male rats 0.82 mg/L and LD50 dermal in rabbits 3100 mg/kg bw/d) Diketene has to be classified as
- acute orally toxic: Xn, R22 - harmful if swallowed; Hazard category 4, H302 - harmful if swallowed
- toxic by inhalation: T, R23 - toxic by inhalation; Hazard category 2, H330 - fatal if inhaled
according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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