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EC number: 203-273-6 | CAS number: 105-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 June 2013 and 01 October 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Municipal sewage treatment plant, Hildesheim, Germany
- Pretreatment: The activated sludge was washed twice with chlorine free tap water. After the second washing the settled sludge was resuspended in mineral salts medium and was maintained in an aerobic condition by aeration for 2.5 hours. Thereafter the sludge was homogenized with a blender. After sedimentation the supernatant was decanted and was maintained in an aerobic condition by aeration with CO2-free air for 5 days. 10 mL/L were used to initiate inoculation.
- Colony forming units in the test solution: 10E+5 - 10E+8 CFU corresponding to 10E+2 - 10E+5 CFU/mL - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Initial conc.:
- 13.8 mg/L
- Based on:
- other: Carbon content in the vessel
- Initial conc.:
- 0.69 other: mg C/mg test item
- Based on:
- other: TOC
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to OECD guideline
- Test temperature: 19.0 - 21.0 °C, up to 26.0 °C on day 25
TEST SYSTEM
- Culturing apparatus: Headspace flasks
- Number of culture flasks/concentration: 3 (on day 28, 5 replicates)
- Measuring equipment: Carbon analyser (Multi N/C 3100)
- Test performed in closed vessels due to significant volatility of test substance: Yes
SAMPLING
- Sampling frequency: Analysis was carried out at test start, twice in the first two weeks and thereafter every 7 days.
CONTROL AND BLANK SYSTEM
- Inoculum blank: mineral medium containing only inoculum
- Toxicity control: mineral medium containing test substance (20 mg/L), reference substance (30 mg/L) and inoculum - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- none
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 87
- Sampling time:
- 28 d
- Remarks on result:
- other: 95% CI: 85-89%
- Details on results:
- The biodegradation of the test item came to 87 % after 28 days. The 10 % level (beginning of biodegradation) was reached on day 3, the pass level of 60 % within the 10-day-window on day 5. In the toxicity control, containing test and reference item, a biodegradation of 92 % was determined after 28 days. The biodegradation of the reference item was not inhibited by the test item in the toxicity control.
- Results with reference substance:
- The functional control (sodium benzoate) reached the pass level of 60 % after 3 days and came to 94 % after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item is readily biodegradable as the pass level of 60 % degradation was reached in a 10-d-window within the 28 days period of the study.
- Executive summary:
The ready biodegradability of the test item was determined with a non adapted activated sludge over a test period of 28 days in the Headspace Test according to OECD 310 and under GLP. The test item was tested at a concentration of 20 mg/L in triplicates, corresponding to a carbon content of 13.8 mg C/L. The biodegradation of the test item was followed by TIC analyses of the quantity of CO2 produced by the respiration of bacteria. The biodegradation of the reference item was not inhibited by the test item in the toxicity control. The biodegradation came to 87 % after 28 days. In conclusion, the test item is readily biodegradable as the pass level of 60 % degradation was reached in a 10-d-window within the 28 days period of the study.
Reference
Description of key information
The test item is readily biodegradable as the pass level of 60 % degradation was reached in a 10-d-window within the 28 days period of the study.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The ready biodegradability of the test item was determined with a non adapted activated sludge over a test period of 28 days in the Headspace Test according to OECD 310 and under GLP. The test item was tested at a concentration of 20 mg/L in triplicates, corresponding to a carbon content of 13.8 mg C/L. The biodegradation of the test item was followed by TIC analyses of the quantity of CO2 produced by the respiration of bacteria. The biodegradation of the reference item was not inhibited by the test item in the toxicity control. The biodegradation came to 87 % after 28 days. In conclusion, the test item is readily biodegradable as the pass level of 60 % degradation was reached in a 10-d-window within the 28 days period of the study.
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