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EC number: 611-005-8 | CAS number: 53513-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-Studie, ausführlich dokumentiert
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- Das vorgegebene Temperaturminimum von 20,0°C wurde in 2 Aquarien kurzzeitig um max. 0,5 K unterschritten.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- D-Penicillamin-Bleisalz
- IUPAC Name:
- D-Penicillamin-Bleisalz
- Reference substance name:
- Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
- IUPAC Name:
- Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Analytical purity: >99.0%
- Lot/batch No.: 120595
- Storage condition of test material: keine besonderen Maßnahmen
- Charakterisierung: graugelbes Pulver, charakteristischer Geruch
- Summenformel: C5H9NO2PbS
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 und 100 mg/L (nominal), nach 0 und 96 Stunden
- Sample storage conditions before analysis: tiefgefroren
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 400 mg Substanz und 400 mg PEG 600 wurden mit künstlichem Süßwasser auf 4 L aufgefüllt und durch mehrstündiges Rühren gelöst.
- Controls: Hilfsstoffkontrolle 400 mg PEG 600 / 4 L künstliches Süßwasser
- Chemical name of vehicle: PEG 600
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrabärbling
- Source: Gunter Rosenheimer, Thalheim
- Length at study initiation (mean): 34 mm
- Feeding during test: nein
ACCLIMATION
- Acclimation period: 7 Tage vor Expositionsbeginn
- Acclimation conditions: mind. 73% O2; 12:12 Stunden dunkel:hell; Temperatur 20,3 - 22,3°C; ca. 1 Fisch/L
- Type of food: Cyclops-Frostfutter
- Feeding frequency: 6x/Woche bis 24 h vor Expositionsbeginn
- Health during acclimation (any mortality observed): keine Mortalität
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 19,5 - 22,2°C
Das vorgegebene Temperaturminimum von 20,0°C wurde in 2 Aquarien kurzzeitig um max. 0,5°C unterschritten. Die Überschreitung hat keine Auswirkungen auf die Versuchstiere. - pH:
- 8,1 - 8,5
- Dissolved oxygen:
- 92 - 100%
- Nominal and measured concentrations:
- 91,9 - 94,5% (Mittel 94%) der Nominalkonzentrationen wurden gemessen. Die Prüfsubstanz war über den Expositionszeitraum stabil.
- Details on test conditions:
- TEST SYSTEM
- Fill volume: 4 L
- Aeration: ja
- No. of organisms per vessel: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: künstliches Süßwasser
- Ca/Mg: 2,04mmol/L Ca, 0,42 mmol/L Mg
OTHER TEST CONDITIONS
- Photoperiod: 12:12 Stunden Hell-Dunkel-Rhythmus
TEST CONCENTRATIONS
- Test concentrations: 100 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Die Prüfkonzentrationen wurden durch analytische Messungen bestätigt (arithm. Mittelwert zu t 0h: 93,9 mg/L; zu 96h: 92,9 mg/L).
- Details on results:
- - Behavioural abnormalities: keine
- Other biological observations: Aussehen der Tiere normal
- Mortality of control: keine
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In einem Limit-Test an Danio rerio nach der EU.C.1 wurde bei einer Konzentration von 100 mg/L keine Wirkung beobachtet.
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