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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 936-276-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Used in EU risk assessment for zinc sulphate, Study well documented, meets generally accepted scientific principles, acceptable for assessment.Read-across justification: Read-across from the most critical and bioavailable constituents (zinc and its compounds):The target substance is a solid inorganic UVCB substance and insoluble in water. Therefore, the transformation/dissolution study (OECD guidance 29) was conducted for the target substance to focus on the most critical bioavailable constituents of the substance. Based on the mineralogical composition, two major constituents of this target substance in addition to lead are zinc and sulphur. Zinc appears in sulphide form in the target substance. According to the 7-day and 28-day transformation/dissolution study at 100, 10 and 1 mg loadings (OECD guidance 29) zinc and sulphur are also soluble from the target substance. Since sulphur can appear either in sulphide or sulphate form in water, the read-across data focuses on the properties of zinc sulphate and other bioavailable forms of zinc. The read-across on zinc and its compounds are used in the chemical safety assessment for those endpoints where the adverse effects of the target substance can be affected by zinc content of the substance. The read-across data was justified in order to avoid unnecessary animal testing.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Litton bionetics
- Year:
- 1 974
- Bibliographic source:
- EU risk assessment report for zinc sulphate, 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (No data about doses, controls, observation frequency, fasting period before study, age at study initiation, housing of animals)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Zinc sulphate
- EC Number:
- 231-793-3
- EC Name:
- Zinc sulphate
- Cas Number:
- 7733-02-0
- Molecular formula:
- H2O4S.Zn
- IUPAC Name:
- zinc sulfate
- Details on test material:
- - Name of test material: Zinc sulphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- for more information refer to reference
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: suspended in 0.85% saline
- Details on oral exposure:
- animals were observed for 10 daysDOSAGE PREPARATION: Solutions were administered at pH between 6.0 and 7.0. Sodium bicarbonate was used to adjust the pH when necessary.CLASS METHOD (if applicable)- Rationale for the selection of the starting dose: A preliminary screening with small groups of 3 animals was carried out The LD50 values were then calculated according to the Litchfield and Wilcoxon method.
- Doses:
- 50 , 100, 500, 1000 and 3000 mg/kg
- No. of animals per sex per dose:
- 5 animals per dose
- Control animals:
- not specified
- Details on study design:
- see reference
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 920 mg/kg bw
- Mortality:
- no information
- Clinical signs:
- other: see reference
- Gross pathology:
- reddened stomach and intestinal mucosa
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 is 920 mg/kg bw
- Executive summary:
In an acute oral study zinc sulphate (type not specified, only “Zinc sulphate, Rayon”) was suspended in 0.85% saline and administered to male Sprague Dawley rats by intubation. Dose levels were 50, 100, 500, 1000 and 3000 mg/kg (5 animals per dose). Animals were observed for ten days. Toxicity signs were reddened stomach and intestinal mucosa. The LD50value was determined as 920 mg/kg bw zinc sulphate.
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