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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 941-396-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles. As the substance is a breakdown product of the target substance, this study is considered valid for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Study of Intra- and Interlaboratory Variability in the Results of Rabbit Eye and Skin Irritation Tests
- Author:
- Weil, C.S. and Scala, R.A.
- Year:
- 1 971
- Bibliographic source:
- Toxicol. Appl. Pharmacol., 19, 276-360
- Reference Type:
- secondary source
- Title:
- OECD SIDS Initial Assessment Report For SIAM 14 - Glycerol
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- http://www.inchem.org/documents/sids/sids/56815.pdf
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- During a study on interlaboratory testing program, glycerol was used together with various other substances. A reference method and non-reference method have been used by the different laboratories.
- GLP compliance:
- no
Test material
- Reference substance name:
- Glycerol
- EC Number:
- 200-289-5
- EC Name:
- Glycerol
- Cas Number:
- 56-81-5
- IUPAC Name:
- glycerol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: Male
- Weight at study initiation: at least 2 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes, other substances used
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 and 27 h after patch removal
- Number of animals:
- 8
- Details on study design:
- TEST SITE
- Area of exposure: Shaved back of animals
- Preparation: Immediately prior to applying the materials the hair was removed from the backs of the animals with electric clippers in such a way as to avoid abrasions. The clipped area was wide enough to accommodate 4 gauze pads without overlapping. The animals were placed in restraint at the time the materials were applied and they remained immobilized during the 24-hr exposure period.
- Type of wrap if used: Four gauze patches, each 1” x 1” cut from nonsterile, 12-ply material, were fixed to the application sites on each animal by means of l/2-inch adhesive tape applied in the shape of an X and wrapped with an impervious Saran film supplied by (Dow Chemical Company) and held in place longitudinally with tape.
SCORING SYSTEM:
Scoring of the reactions was based on the amount of erythema, edema, and necrosis found. Necrosis was defined in this instance as “chemical denaturation of tissue sufficiently severe to result in fibrotic replacement (scar tissue). Superficial eschar which heals without scar is not classified as necrosis.” The skin reacion scores of each animal in each category at 24 and 72 hr after application were added. The total score for all 8 rabbits was divided by 16 to yield a Primary Irritation (PI) score for a given material.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Primal Irritation Score
- Basis:
- mean
- Time point:
- other: 24 and 72 h
- Score:
- 0 - < 0.4
- Max. score:
- 30
- Reversibility:
- no data
- Irritant / corrosive response data:
- All 14 participating laboartories found glycerol to be no-irritating bases on the PIS of <0.4.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test results of the different laboartory participating the study show that Glycerol can be regarded as not irritating to skin.
- Executive summary:
Glycerol was not found to be irritating to skin in survey evaluating intra- and interlaboratory variabilities in testing on skin and eye irritation. Beside laboratory-specific methods, a reference method has been used by the laboratories resulting in a primary irritation score to compare the results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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