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Diss Factsheets
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EC number: 204-065-8 | CAS number: 115-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Sep - 4 Oct 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was selected as the key study because the information provided for the hazard endpoint includes information at concentrations above the limit for classification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- only males were used
- Principles of method if other than guideline:
- Ten male rats were exposed to the test substance for a 4-hour exposure period at concentrations of 84000, 121000, 152000, 169000, or 205000 ppm. Clinical signs and body weights were evaluated during the 14-day recovery period. Necropsies were performed on surviving rats after the 14-day recovery period.
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl ether
- EC Number:
- 204-065-8
- EC Name:
- Dimethyl ether
- Cas Number:
- 115-10-6
- Molecular formula:
- C2H6O
- IUPAC Name:
- dimethyl ether
- Details on test material:
- - Physical state: DME is a gas which was received as a liquid under pressure
- Purity: 99.9%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7-8 weeks
- Weight at study initiation: 204-301 g
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: rats were kept for a 10d quarantine period prior to selection for the test
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remark on MMAD/GSD:
- Not applicable as DME is a gas.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 20 L glass exposure chamber.
- Method of holding animals in test chamber: chamber volume was kept as small as was practical, handling of rats was minimized
- Atmosphere generation: Atmospheres were generated by means of a single stage regulator through a flow meter (with a stainless steel float) directly into the top of a 20-L glass exposure chamber. Dilution air flowing through a flow meter (with a stainless steel float) joined the DME stream at the top of the chamber. The air/DME flow was maintained at 10 L/min.
TEST ATMOSPHERE
- Brief description of analytical method used: GC - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 8.4; 12.1; 15.2; 16.9; 20.5% (84000; 121000; 152000; 169000; 205000 ppm)
- No. of animals per sex per dose:
- 10 males per concentration; 2 males per cage
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- probit analysis
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 164 000 ppm
- Based on:
- test mat.
- 95% CL:
- 142 000 - 203 000
- Exp. duration:
- 4 h
- Mortality:
- Mortality of 0/10, 3/10, 2/10, 7/10, and 7/10 occurred in the 84000, 121000, 152000, 169000, and 205000 ppm groups, respectively. All but one death (205000 ppm) occurred during the exposures.
84000 ppm: ataxia, anesthesia in 2 hours, shallow respiration, lung noise (post exposure); >84000 ppm: ataxia, anesthesia in 15-30 min, heavy respiration, coma, lung noise (post exposure) - Clinical signs:
- other: Clinical observations for the 4 highest test concentration groups were similar. Anesthesia was achieved more rapidly at the higher concentrations. Observations were: ataxia, unresponsiveness to noise, anesthesia in 15 to 30 min with heavy respirations
- Body weight:
- Slight body weight loss 1-2 days post-exposure in the 4 highest test concentration groups
- Other findings:
- Post-exposure survivors rapidly awoke and showed no clinical signs, other than transient weight loss for 1-2 days and sporadic lung noise. All but 1/19 deaths occurred during the exposure.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 4-hour LC50 = 164000 ppm
The study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability). - Executive summary:
A 4-hour whole-body inhalation LC50 study was conducted in male ChR-CD® rats. During exposure, the rats demonstrated ataxia, anesthesia, coma, and death. Post-exposure, survivors rapidly awoke and showed no clinical signs other than transient weight loss for 1-2 days and sporadic lung noise. All but 1/19 deaths occurred during the exposures. The 4-h LC50 in male ChR-CD® rats is 16.4% (164000 ppm or 309 mg/L) with 95% confidence limits of 14.2 and 20.3%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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