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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-065-8 | CAS number: 115-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Rapidly absorbed and distributed following exposure by inhalation. No bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - inhalation (%):
- 100
Additional information
DME is a gas and potential exposure would likely occur via the inhalation route. Therefore, no oral or dermal route absorptions are indicated. The absorption via inhalation involves passive diffusion until equilibrium is reached between partial DME pressure in the tissues and the air.
The toxicokinetics of DME in rats were evaluated following 1-h inhalation of 1000 ppm (1.9 mg/L) and 30 min to concentrations between 745 and 2000 ppm (between 1.4 and 3.8 mg/L) DME. Test substance concentrations were determined in rat blood, heart, lungs, liver, spleen, kidneys, fat, muscles and brain. The test substance was absorbed into blood and distributed widely to organs and tissues. The increases in test substance concentrations in these organs/tissues, including brain, were rapid and similar except for a slower increase in fat and muscles. Test substance concentrations in fat were approximately 30% higher than in other tissues. After a 1-h exposure to 1000 ppm, test substance levels decreased rapidly and equally (except for fat which was cleared slightly slower). Following a single short spraying application in humans, test substance concentrations in blood were low and decreased rapidly following the exposure.
It is concluded that the test substance is rapidly absorbed into the blood and tissues, is quickly eliminated once the exposure is terminated, and has a low bioaccumulation potential in rats and humans.
In comparing species, one should realize that reaching equilibrium between tissue concentration and the outside concentration in air takes time, which increases with increasing size of the organism. As a consequence, the duration of an internal peak concentration will be shorter in humans compared to rats, and possibly not even reaching the equilibrium level for the peak exposure when duration is relative short. The area under the curve will be the same, however, it is considered that effects by DME are driven by peak exposures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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