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EC number: 500-236-9 | CAS number: 68920-66-1 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 - 23 Oct 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 1987
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 2020
- Deviations:
- yes
- Remarks:
- no stepwise testing, no treatment with systemic analgesic/ topical anaesthesia of the animals / animal eyes; scoring according to Draize reported until reading time point 72 h only although effects were observed up to Day 7
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 1992
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- EC Number:
- 500-236-9
- EC Name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- Cas Number:
- 68920-66-1
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- Alcohols, C16-18(even numbered) and C18 unsaturated, ethoxylated < 2.5 EO
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Mol:Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding and Research Centre, Ejby, Lille Skensved, Denmark
- Weight at study initiation: 2.0 – 2.1 kg
- Housing: Individually, in PPO cages (floor area 2576 cm^2) with perflorated floor
- Diet: Altromin 2123 (Altromin, Lage, Germany), ad libitum
- Water: Drinking water acidified with hydrochloric acid (to pH 2.5), ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): 55 ± 15
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- single administration without washing
- Observation period (in vivo):
- 7 days
Reading time points: 1, 24, 48 and 72 h and 7 days after test item instillation - Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- SCORING SYSTEM:
Draize scoring
TOOL USED TO ASSESS SCORE: fluorescein and UV light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibiity not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 and #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks:
- 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- One hour after test item instillation, 2/3 rabbits showed diffuse redness (score 2) and 1/3 animals showed slight redness (score 1) of the conjunctiva. In addition, 2/3 animals showed an obvious swelling of the conjunctiva (score 2) while the third rabbit showed a slight swelling (score 1). Additionally, discharge with moistening of lids and hiars just adjacent to lids was observed in 2/3 animals.
At the 24 and 48 h readings, 2/3 animals showed diffuse redness (score 2) and obvious swelling (score 2) of the conjunctiva, while the last animal showed only slight redness (score 1) and swelling (score 1) of the conjunctiva.
72 h after administration of the test item, slight redness of the conjunctiva (score 1) was observed in all 3 rabbits, obvious swelling of the conjunctiva (score 2) was noted in 1/3 animals and slight swelling of the conjunctiva was observed in 2/3 animals.
At the day 7 reading, no signs of eye irritation were observed. However, the outer side of the lower lid in all 3 animals contained dried crusts with hairs, which could be removed from the lids.
Any other information on results incl. tables
Table 1: Eye irritation results
Rabbit | Corneal opacity | Iris | Conjunctival redness | Conjunctival chemosis | Conjunctival discharge | ||||||||||
1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
1 h | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 1 | 2 | 2 | 0 | 2 | 2 |
24 h | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 2 | 2 | 1 | 0 | 0 | 0 |
48 h | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 2 | 2 | 1 | 0 | 0 | 0 |
72 h | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 |
Mean 24/48/72 h | 0 | 0 | 0 | 0 | 0 | 0 | 1.67 | 1.67 | 1.00 | 2.00 | 1.67 | 1.00 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
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