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EC number: 500-236-9 | CAS number: 68920-66-1 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 02 - 24 Dec 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 1992
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 2015
- Deviations:
- yes
- Remarks:
- no stepwise testing performed, age of the animals not reported, scoring according to Draize was reported until reading time point 72 h only although effects were observed up to the 14 day reading
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 1992
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- EC Number:
- 500-236-9
- EC Name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- Cas Number:
- 68920-66-1
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- Alcohols, C16-18(even numbered) and C18 unsaturated, ethoxylated < 2.5 EO
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Mol:Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding and Research Centre, Ejby, Lille Skensved, Denmark
- Weight at study initiation: 2.2 – 2.5 kg
- Housing: Individually, in PPO cages (floor area 2576 cm^2) with perflorated floor
- Diet: Altromin 2123 (Altromin, Lage, Germany), ad libitum
- Water: Drinking water acidified with hydrochloric acid (to pH 2.5), ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): 55 ± 15
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 21 days
Reading time points: 1, 24, 48 and 72 h and 7, 14 and 21 days - Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: A clipped area on the back of the animals of 10 x 10 cm. The clipped area was divided into four fields, the two posterior fields were used for testing. The test item was applied on two 2.5 x 2.5 cm 16-layer gauze patches and placed on the test site.
- Type of wrap if used: The gauze patches were secured with 2.5 cm wide adhesive tape and fixed with Micropore tape, 5cm width, loosely wound round the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The treated skin was cleaned with mild soap and lukewarm water.
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS : 1, 24, 48 and 72 h and 7, 14 and 21 days
SCORING SYSTEM: Draize scoring
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- animal: #1 and #3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritant / corrosive response data:
- Skin reactions were observed from the 24-hour reading onwards in all animals. At the 24 h reading, all animals showed slight erythema (score 1) and 1/3 animals showed slight edema (score 1). At the 48 and 72 h readings, 3/3 animals showed moderate to severe erythema (score 3) and slight edema (score 2). 7 days after application of the test article, all animals showed massive scab formation on the test areas. On study Day 14, 2/3 animals showed larger residues of scales on both test areas, 1/3 animals showed slight redness and residues of scales on both test areas and in 2/3 animals shiny skin was observed. 21 days after administration, all animals were free of lesions and showed complete hair and intact skin.
Any other information on results incl. tables
Table 1: Results on skin irritation for individual animals: erythema scores
Rabbit | Test field | Erythema | ||||
1 h | 24 h | 48 h | 72 h | Mean 24/48/72 h | ||
1 | left | 0 | 1 | 3 | 3 | 2.33 |
right | 0 | 1 | 3 | 3 | ||
2 | left | 0 | 1 | 3 | 3 | 2.33 |
right | 0 | 1 | 3 | 3 | ||
3 | left | 0 | 1 | 3 | 3 | 2.33 |
right | 0 | 1 | 3 | 3 |
Table 2: Results on skin irritation for individual animals: edema scores
Rabbit | Edema | |||||
1 h | 24 h | 48 h | 72 h | Mean 24/48/72 h | ||
1 | left | 0 | 0 | 2 | 2 | 1.33 |
right | 0 | 0 | 2 | 2 | ||
2 | left | 0 | 1 | 2 | 2 | 1.67 |
right | 0 | 1 | 2 | 2 | ||
3 | left | 0 | 0 | 2 | 2 | 1.33 |
right | 0 | 0 | 2 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Skin irrit. 2, H315. Classification according to Regulation (EC) No. 1272/2008 (CLP/EU GHS).
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