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EC number: 231-157-5 | CAS number: 7440-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Intestinal absorption of trace quantities of chromium.
- Author:
- Donaldson, R. M., Jr. and R. F. Barreras
- Year:
- 1 966
- Bibliographic source:
- J Lab Clin Med.68(3): 484-93.
Materials and methods
- Type of study / information:
- Absorption and excretion of radiolabelled trivalent chromium studied in human volunteers.
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Absorption and excretion of radiolabelled trivalent chromium was studied in human volunteers.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chromium chloride
- Cas Number:
- 10025-73-7
- Molecular formula:
- CrCl3
- IUPAC Name:
- Chromium chloride
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Volunteer patients (n=6) were orally given a dose of 20 ng of Cr[51]Cl3 containing 0.5 to 1 µc of radioactivity. In two patients, the dose was injected directly into the duodenum through a fine tube. For measuring intestinal absorption, an intestinal perfusion technique was applied.
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: Single oral dose, or direct injection into the duodenum through a polyvinylchloride tube.
TYPE OF EXPOSURE MEASUREMENT: / Biomonitoring (urine and faeces)
EXPOSURE LEVELS: 20 ng
EXPOSURE PERIOD: single dose
POSTEXPOSURE PERIOD: 6 days of follow-up. urine was collected for 24 h and faeces for 6 days.
Results and discussion
- Results:
- The mean recovery of faecal radioactivity was 99.6% after oral administration and 93.7% after duodenal administration. The urinary excretion was 0.5% and 0.6% after oral and duodenal exposure, respectively.
Applicant's summary and conclusion
- Conclusions:
- The oral bioavailability of trivalent chromium was very low, as tested in human volunteers.
- Executive summary:
In the study by Donaldson and Barreras (1966), volunteer patients (n=6) were orally given a dose of 20 ng of Cr[51]Cl3 containing 0.5 to 1 µc of radioactivity. In two patients, the dose was injected directly into the duodenum through a fine tube. For measuring intestinal absorption, an intestinal perfusion technique was applied. The mean recovery of faecal radioactivity was 99.6% after oral administration and 93.7% after duodenal administration. The urinary excretion was 0.5% and 0.6% after oral and duodenal exposure, respectively.
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