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EC number: 229-146-5 | CAS number: 6419-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No details on test substance, animals and environmental conditions.
- Principles of method if other than guideline:
- Method: Insufficient detail to fully assess comparability with OECD test guideline.
- GLP compliance:
- no
Test material
- Reference substance name:
- Nitrilotrimethylenetris(phosphonic acid)
- EC Number:
- 229-146-5
- EC Name:
- Nitrilotrimethylenetris(phosphonic acid)
- Cas Number:
- 6419-19-8
- Molecular formula:
- C3H12NO9P3
- IUPAC Name:
- nitrilotrimethylenetris(phosphonic acid)
Constituent 1
- Specific details on test material used for the study:
- Anhydrous sample without details of substance identity.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 mg of a finely ground powder
placed into the conjunctival sac of the right eye.
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- Seven days
- Number of animals or in vitro replicates:
- Three
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, with warm isotonic saline solution.
- Time after start of exposure: 24 hours.
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: No data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Average maximum score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 53.6
- Max. score:
- 110
- Reversibility:
- not fully reversible within: Seven days
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
- Irritant / corrosive response data:
- Oedema with the lids about half closed, copious discharge, moderate redness of the conjunctivae and mild corneal cloudiness were recorded by one hour after instillation. The lids were nearly closed overnight and there was moderate iris conjunction (24 hours). Improvement followed irrigation so that within five days iris clarity was nearly normal in two animals. Also, discharge had ceased and oedema had reduced considerably.
- Other effects:
- Signs of discomfort or pain were pawing at the eyes.
Any other information on results incl. tables
Table 1 Summary of eye irritation scores
Animal Number | Numerical Evaluation* at the end of: | |||||
1 hour | 24 hours | 48 hours | 72 hours | 120 hours | 168 hours | |
1 - Male | 32 | 57 | 48 | 39 | 19 | 8 |
2 - Female | 25 | 49 | 41 | 31 | 10 | 2 |
3 - Male | 27 | 55 | 44 | 29 | 8 | 2 |
Average | 28.0 | 53.6 | 44.3 | 33.0 | 12.3 | 4.0 |
*Results given as one overall score per animal, not broken down into effects on cornea/iris/conjunctivae.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- In an in vivo eye irritation study, conducted prior to the adoption of OECD test guidelines and GLP, finely ground powder of ATMP-H (CAS 6419-19-8; EC No., 229-146-5; anhydrous sample without details of substance identity) caused moderately severe eye irritation to rabbit eyes.
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