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Diss Factsheets
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EC number: 231-555-9 | CAS number: 7632-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Shuval and Gruener (1972; 1977) reported about the epidemiological and toxicological aspects of nitrates and nitrites in the environment. The authors concluded that the nitrite levels increased in fetal blood with a lag of about 20 min behind the mother; this increase was followed by a rise in MetHb levels. The kinetic picture was similar between the dam and the fetuses. The threshold of the transplacental transfer effect was observed at 2.5 mg NaNO2/kg b.w. Higher doses caused a rapid increase in the NaNO2 level of maternal and fetal blood. The results of this study demonstrated that nitrites were apparently not transferred in appreciable amounts to suckling rats (Shuval and Gruener, 1972).
In rats which received drinking water with the highest concentrations of NaNO2 (1000, 2000 or 3000 mg/l), the levels of MetHb were increased after 1 month of treatment and throughout the rest of the study. The group treated with NaNO2 at 1000 mg/l (100 mg/kg b.w.) showed what might be considered subclinical levels, while groups exposed to 2000 and 3000 mg/l (200 or 300 mg/kg b.w.), exhibited levels which would be considered clinically significant in humans. After a single i.p. administration of NaNO2, maximal concentrations of MetHb were found at 20 - 90 min later and then declined in a long recovery phase with complete recovery followed a first order reaction with a t1/2 of about 90 minutes. When levels of the methemoglobin reductase were compared among groups at each time of the determination, there was a definite decrease in enzyme activity in groups exposed to nitrite after a lag period of 1 month of exposure and in recovery to control levels toward the end of the experiment (Shuval and Gruener, 1977).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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