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EC number: 266-930-6 | CAS number: 67701-06-8 This substance is identified by SDA Substance Name: C14-C18 and C16-C18 unsaturated alkyl carboxylic acid and SDA Reporting Number: 04-005-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects on invertebrates up to the limit of water solubility.
LC50 for marine invertebrates: 357.5 mg/L in brackish test water
Key value for chemical safety assessment
Additional information
Studies are available for the pure homologue members of the fatty acid category. In addition some studies are summarized for certain fatty acid mixtures. Generally it could be stated that toxicity of fatty acids to aquatic organisms increases with increasing chain length up to the water solubility limit at a chain length of C12. For longer chains, no effects at saturation are observed.
For the fatty acid mixture under consideration, which contains as main homologues C16 and C18, one study is available for a marine copepod. In addition read-across is performed to studies available for the pure homologues C16 (palmitic acid, CAS 57 -10 -3) and C18 (stearic acid, CAS 57 -11 -4). For the evaluation of the mixture only studies available for the pure homologues which were determined as key studies or used to cover the endpoint via weight of evidence were chosen for read-across. All linked studies conducted with the pure homologues were used in a weight of evidence approach to cover the endpoint "short-term toxicity to invertebrates" for the considered fatty acid mixture.
Fatty acid homologue |
LC/EC50 |
Water solubility* |
Test design and species |
Reference |
C16 - CAS 57-10-3 palmitic acid |
> 4.8 mg/L (measured, geom. mean) |
< 0.05 at 20 °C |
48 h, static,Daphnia magna |
NITE, 2000a |
C18 - CAS 57-11-4 stearic acid |
> 32 mg/L (nominal) |
insoluble |
47 h, static,Daphnia magna |
Hooftman, 1991 |
> 20 mg/L (nominal) |
Artemia salina, saltwater |
Curtis et al.,1970 |
||
C14 - 18, C16 - 18 unsatd.- |
357.5 mg/L |
No data available for brackish water |
48 h, semi-static,Acartia tonsa, |
Thomson, 2006 |
* see category justification
Palmitic acid (C16: CAS 57 -10 -3) was tested on daphnids in a 48 h static test (NITE, 2000a) under GLP. In the limit test a nominal test concentration of 10 mg/L (corresponding to a measured concentration (geom. mean) of 4.8 mg/L) was used. No effects on mobility of daphnids could be observed during the test period of 48 h. Thus the EC50 is reported to be above 4.8 mg/L (measured concentration) which is far above the limit of water solubililty (see table above and category justification).
For the evaluation of toxic effects of stearic acid (C18: CAS 57 -11 -4) on aquatic invertebrates two studies were taken into account. A static test was conducted on daphnids over 47 hours according to the EU method C.2 in compliance with GLP requirements (Hooftman, 1991). Different concentrations were tested in the study using test water of different hardness. In this study the EC50 -value was reported to be above 32 mg/L (nominal). This result is in line with the EC50 given in the other available study for stearic acid (C18: CAS 57 -11 -4). In the publication of Curtis et al. (1970) Artemia salina were tested. The authors reported an EC50 > 20 mg/L.
The C14 - C18 and C16 - C18 unsaturated fatty acid mixture (CAS 67701 -06 -8) was tested on the marine copepod Acartia tonsa using brackish water (Thomson, 2006). The semi-static test was conducted according to ISO 14699 in accordance with GLP-requirements. Different test concentrations were used and the LC50 after 48 h was reported to be 357.5 mg/L.
Concluding from the results reported for the pure homologues C16 and C18 no toxic effects on invertebrates within the range of water solubility are expected for the considered fatty acid mixture. The LC50 determined for marine species was reported to be 357.5 mg/L tested in brackish water.
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