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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 221-605-8 | CAS number: 3159-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: GLP-status not known, guideline not known, information from a peer-reviewed, published review article. Notable limitations in design and/or reporting, reliability not known.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- publication
- Title:
- Percutaneous absorption of some anionic surfactants
- Author:
- Howes D
- Year:
- 1 975
- Bibliographic source:
- Journal of the Society of Cosmetic Chemistry, vol. 26, issue 1, pp. 47-63 cited in CIR (1982)
Materials and methods
- Objective of study:
- distribution
- excretion
- metabolism
- other: Storage
- Principles of method if other than guideline:
- - Method: 6 animals, 3 injected subcutaneously and 3 injected intraperitoneally, were exposed to aqueous samples of radiolabelled sodium stearate and the excretion, metabolism and absorption assessed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium stearate
- EC Number:
- 212-490-5
- EC Name:
- Sodium stearate
- Cas Number:
- 822-16-2
- IUPAC Name:
- sodium stearate
- Test material form:
- other: Aqueous solution
- Details on test material:
- No data reported
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data reported
Administration / exposure
- Route of administration:
- other: Injection: three subcutaneously and three intraperitoneally
- Vehicle:
- water
- Details on exposure:
- No data reported
- Duration and frequency of treatment / exposure:
- No data reported
Doses / concentrations
- Remarks:
- Doses / Concentrations:
- Doses: 0.1 or 0.5 mL aqueous samples
- Concentration: 0.18 mg 14C sodium stearate
- No. of animals per sex per dose / concentration:
- - Number of animals: 6 in total
- Number of animals injected subcutaneously: 3 animals
- Number of animals injected intraperitoneally: 3 animals - Control animals:
- not specified
- Positive control reference chemical:
- No data reported
- Details on study design:
- No data reported
- Details on dosing and sampling:
- No data reported
- Statistics:
- No data reported
Results and discussion
- Preliminary studies:
- No data reported
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- Negligible amounts (0.1% of 0.18 mg dose) of the 14C appeared in the urine or faeces
- Type:
- metabolism
- Results:
- Expired CO2 contained 38 ± 9% of the 0.18 mg dose of the 14C
- Type:
- absorption
- Results:
- The carcass retained 56 ± 16 % of 0.18 mg dose of the 14 C
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Adsorption: The carcass retained 56 ± 16 % of 0.18 mg dose of the 14 C
- Details on distribution in tissues:
- No data reported
- Details on excretion:
- - Excretion: Negligible amounts (0.1% of 0.18 mg dose) of the 14C appeared in the urine or feces
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- No data reported
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- No data reported
Applicant's summary and conclusion
- Conclusions:
- The injection of rats subcutaneously or intraperitoneally with 0.18 mg 14C sodium stearate led to 0.1 % of the applied 14C dose being excreted, 38 ± 9 % being expired and 56 ± 16 % being retained in the carcass.
- Executive summary:
The injection of rats subcutaneously or intraperitoneally with 0.18 mg 14C sodium stearate led to 0.1 % of the applied 14C dose being excreted, 38 ± 9 % being expired and 56 ± 16 % being retained in the carcass. No information on the test methods used is available in the publication (CIR 1982). However, this information is taken from a peer reviewed article and can be considered adequate for use for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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