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EC number: 482-330-9 | CAS number: 144020-22-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Description of key information
Under the conditions of the test (OECD TG 422, GLP), the systemic NOAEL was determined to be 150 and mg/kg bw based on the increase of liver weights effect. The fertility NOAEL is >= 500 mg/kg bw based on the absence of an adverse effect. The developmental NOAEL is >= 500 mg/kg bw based on the absence of an adverse effect.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Additional information
This executive summary is the same as presented in the repeated doses toxicity section.
In a combined 28-days repeated dose toxicity study with reproduction/developmental screening performed in accordance with OECD TG 422 and GLP, the substance was administrated via oral gavage to Sprague-Dawley rats (10 per dose per sex) at dosages of 50, 150 and 500 mg test item/kg bw/day. Control animals received the vehicle, corn oil, alone. All parameters measured from the OECD TG 422 have been recorded.
Clinical signs: No adverse effects considered to be associated with treatment were observed for mortality, clinical signs, neurobehavior, bodyweight and food consumption.
Haematology: No adverse effects considered to be associated with treatment were observed.
Biochemical parameters: No adverse effects considered to be associated with treatment were observed.
Organ effects weight: Absolute and body weight adjusted liver weights were increased in all groups of treated males with a dose response apparent and statistical significance attained at 500 and 150 mg/kg/day for the adjusted values. Compared to Control, absolute and adjusted kidney weights were also increased in all groups of treated males with statistical significance attained for the adjusted values at 500 mg/kg/day, but there was no dose response apparent. On Day 13 of lactation, absolute and body weight adjusted liver weights for females that received 500 or 150 mg/kg/day were higher with statistical significance attained at 500 mg/kg/day for adjusted weights. Absolute and body weight adjusted spleen weights were lower in all treated females statistical significance was attained for all treated groups for the adjusted weights.
Macroscopy and histopathology: No adverse effects considered to be associated with treatment were observed.
Fertility: No adverse effects considered to be associated with treatment were observed.
Development: No adverse effects considered to be associated with treatment were observed.
Under the conditions of this study, the NOAEL for repeated dose toxicity was established to be 150 mg/kg bw/day for males and females, based on the increase in liver weights effect. The fertility NOAEL is >= 500 mg/kg bw based on absence of reproductive toxicity up to the highest dose level tested. The developmental NOAEL is >= 500mg/kg bw based on absence of developmental toxicity up to the highest dose level tested. Based on the results of the available repeated dose studies the substance does not have to be classified for reproductive toxicity (fertility and developmental toxicity) according to EU CLP (EC 1272/2008 and its amendments).
Effects on developmental toxicity
Description of key information
See "toxicity to reproduction part" for more information.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Based on the results of the available Repeated dose study and Reproductive / Developmental toxicity screening the substance does not have to be classified for reproductive toxicity (fertility and developmental toxicity) according to EU CLP (EC 1272/2008 and its amendments).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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