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Diss Factsheets
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EC number: 204-695-3 | CAS number: 124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD Guideline 401 in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Octadecylamine
- EC Number:
- 204-695-3
- EC Name:
- Octadecylamine
- Cas Number:
- 124-30-1
- Molecular formula:
- C18H39N
- IUPAC Name:
- octadecan-1-amine
- Test material form:
- other: wax
- Details on test material:
- Chemical name: Octadecylamine
EC no.: 204-690-6
To the best of knowledge, the sample used is representative to the boundary composition shared and agreed by each registrant.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Age at study initiation:
- male: ca. 7 weeks
- female: ca. 8 weeks
- Weight at study initiation:
- male:
- mean: 195 g
- min: 178 g
- max: 208 g
- sd: +- 11g
- n = 5
- female:
- mean: 189 g
- min: 186 g
- max: 192 g
- sd: +- 3g
- n = 5
- Housing: fully airconditioned rooms, makrolon cages on soft wood chips in groups of 5 animals
- Diet (e.g. ad libitum): Altromin 1324 ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: min. 5 days
- no feeding 16 hrs prior and 3-4 hours past application of the test-substance
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-3 °C
- Humidity (%): 50 +- 20 %
- Photoperiod (hrs dark / hrs light): 12 / 12 hrs
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- - Concentration in vehicle: 20% (w/v)
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations once daily / Weighing once weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 2000 mg/kg: 1 / 5
- Clinical signs:
- other: disequilibrium, dyspnoe, convulsions
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The median lethal dose of Octadecylamine (LD50) was greater 2000 mg per kg body weight in both male and female rats. Based on the result of this study Octadecylamine is not subject for labelling and classification requirements according to regulatory requirements
- Executive summary:
The study of the acute oral toxicity of Genamin 18 R 100 D (octadecylamine) to 5 male and 5 female Wistar rats resulted in a median lethal dose (LD50) of greater 2000 mg/kg body weight. After the application of 2000 mg/kg body weight one male animal deceased on day four after application. Animals showed beside unspecific signs of poisoning impairment of breathing and in motion. For one male animal a swollen stomach was observed additionally. An impairment (interference) of the body-weight development was not observed. Macroscopic findings of toxicological significance were not observed during gross pathology at the end of the observation period.
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