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EC number: 262-679-1 | CAS number: 61260-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Dec 1984 - 22 Jan 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted May 12, 1981
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
- EC Number:
- 262-679-1
- EC Name:
- N,N'-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
- Cas Number:
- 61260-55-7
- Molecular formula:
- C24H50N4
- IUPAC Name:
- N1,N6-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, D-4799 Borchen
- Weight at study initiation: males: 172 g; females: 130 g
- Fasting period before study: 16 hours
- Housing: 1-5 animals in type III Makrolon
- Diet (ad libitum): R10 complete feed for rats, Ssniff Spezialfutter GmbH, D-4770 Soest
- Water (ad libitum): tap water
- Acclimation period: 4-8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 cm³/kg bw
DOSAGE PREPARATION: The product was dissolved in maize germ oil at approximately 60 °C and administered at 40 °C. - Doses:
- 501, 631, 794, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: before the treatment and 1, 7, 14 days after the treatment
- Necropsy of survivors performed: yes: All of the animals sacrificed at the end of the investigation and animals which died during the study period were dissected and macroscopically examined, and the findings were recorded.
- Other examinations performed: clinical signs: Up to six hours after the treatment and then daily, the onset, type and duration of all signs of toxicity and the time of death were noted. - Statistics:
- The means (x) of the bodyweights were calculated. The LD50 is generally determined as described by Litchfield and Wilcoxon and reported with 95% confidence limits (J. Pharmacol. Exp. Ther. 96, 1949, 99).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 820 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 703 - 956
- Mortality:
- see Tab.1 (Any other information on results incl. tables)
- Clinical signs:
- other: Symptoms which occurred from approximately 30 minutes after administration were ruffled fur, in some case prone position, staggering, twitching, mild to strong sedation and ataxia, dark eyes and tremor and later crouched posture, hypothermia and, at the h
- Gross pathology:
- In the post-mortem dissections, hyperaemia of the gastric mucosa and small intestine mucosa, stasis of the liver and dark-coloured liver were observed. Dissection at the end of the test revealed in some animals hyperaemia of the gastric mucosa and small intestine mucosa, spots on both kidneys in 2 animals and in 2 animals only on the right kidney.
Any other information on results incl. tables
Tab.1 Acute oral toxicity (LD50) for rats
Dose mg/kg |
Sex |
Toxicological result |
Death occurred within (h) |
LD50 mg/kg |
501 |
male |
0/5/5 * |
|
|
|
female |
0/5/5 |
- |
|
|
|
|
|
|
631 |
male |
2/5/5 |
|
|
|
female |
0/5/5 |
4 |
|
|
|
|
|
|
794 |
male |
4/5/5 |
|
820 (703-956) slope function S = 1.36 |
|
female |
2/5/5 |
24 |
|
|
|
|
|
|
1000 |
male |
3/5/5 |
|
|
|
female |
3/5/5 |
24 |
|
*number of animals which died/number of animals with signs/number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- In the determination of the acute oral toxicity on male and female rats it was found that the LD50 of the test substance is 820 mg/kg bw. Under the experimental conditions described, the test substance fulfils the GHS criteria for classification into the acute toxicity Category IV.
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