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EC number: 243-815-9 | CAS number: 20427-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with Good laboratory Practice and internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Copper dihydroxide
- EC Number:
- 243-815-9
- EC Name:
- Copper dihydroxide
- Cas Number:
- 20427-59-2
- Molecular formula:
- CuH4O2
- IUPAC Name:
- copper(2+) dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Not stated
- Composition of test material, percentage of components: Not stated
- Lot/batch No.: 0210576133
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six female New Zealand white rabbits weighing approximately 2.0 to 2.5 kg were housed singly and acclimatised prior to dosing.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- Test material was moistened with deionised water and made into a slurry prior to application.
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of test material mixed with 0.6 mL of deionised water.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- Six
- Details on study design:
- On the day prior to application, an area on the dorsal area of the trunk of each animal was shaved free of fur. The following day, 0.5 g of test material mixed with 0.6 mL of deionised water was evenly applied to a 2 x 3 cm gauze surgical patch backed by semi-occlusive tape and an elastic bandage. The complete dressing was then wrapped around the trunk of each animal. After 4 hours, the dressings were removed and any residual test substance was rinsed off with water and a paper towel.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No erythema was recorded. Slight oedema (score 1) was noted in one animal after 30 to 60 minutes which was likely to be due to the compressive bandage. No effects were recorded in other animals or at other assessment times. The mean score (24 to 72 hours) was 0.0.
- Other effects:
- None.
Any other information on results incl. tables
Table 1. Summary of individual and mean skin irritation scores according to Draize
Assessment time |
Scores according to Draize for animal number |
|||||
2823 |
2824 |
2825 |
2826 |
2827 |
2828 |
|
Erythema |
||||||
30 to 60 mins. |
0 |
0 |
0 |
0 |
0 |
0 |
24 hours |
0 |
0 |
0 |
0 |
0 |
0 |
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score |
0.0 |
|||||
Oedema |
||||||
30 to 60 mins. |
0 |
1 |
0 |
0 |
0 |
0 |
24 hours |
0 |
0 |
0 |
0 |
0 |
0 |
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Copper dihydroxide was not irritating to rabbit skin (means scores 24 to 72 hours for erythema and oedema were 0.0).
Classification according to Directive 67/548/EEC: Not classified.
Classification according to CLP/GHS: Not classified. - Executive summary:
A GLP-compliant study was conducted in accordance with the requirements of US EPA 81-5 without significant deviation. Copper dihydroxide was moistened with deionised water and made into a slurry prior to application. Six female New Zealand white rabbits weighing approximately 2.0 to 2.5 kg were housed singly and acclimatised prior to dosing. On the day prior to application, an area on the dorsal area of the trunk of each animal was shaved free of fur. The following day, 0.5 g of test material mixed with 0.6 mL of deionised water was evenly applied to a 2 x 3 cm gauze surgical patch backed by semi-occlusive tape and an elastic bandage. The complete dressing was then wrapped around the trunk of each animal. After 4 hours, the dressings were removed and any residual test substance was rinsed off with water and a paper towel. Animals were examined for signs of irritation after 30 to 60 minutes and then after 24, 48 and 72 hours, and effects scored according to Draize.
No erythema was recorded. Slight oedema (score 1) was noted in one animal after 30 to 60 minutes which was likely to be due to the compressive bandage. No effects were recorded in other animals or at other assessment times. The mean score (24 to 72 hours) was 0.0. Dicopper dihydroxide is not classified as a skin irritant.
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