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EC number: 306-479-5 | CAS number: 97280-83-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study (OECD 403 Inhalation Hazard Test). Deviation: 6 animals (3 males and 3 females) were used
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- 6 animals (3 males and 3 females) were used
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
Test material
- Reference substance name:
- Dodecene, branched
- EC Number:
- 306-479-5
- EC Name:
- Dodecene, branched
- Cas Number:
- 97280-83-6
- Molecular formula:
- C12 H24
- IUPAC Name:
- (2Z)-4-methylundec-2-ene
- Details on test material:
- - Name of test material (as cited in study report): Isododecene
- Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach, FRG
- Age at study initiation: about 8-9 weeks
- Weight at study initiation: mean weight of males was 283 g, mean weight of females was 192 g
- Housing: in groups of three in type D III wire mesh cages (without bedding)
- Diet (e.g. ad libitum): ad libitum in the period without exposure (KLIBA 24-343-4 rat/mouse laboratory diet)
- Water (e.g. ad libitum): ad libitum in the period without exposure
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24°C
- Humidity (%): 30 - 70%
- Photoperiod (hrs dark / hrs light): 12/12
There were no deviations from these set conditions which might have adversely affected the results of the study.
Animal identification: by dye marks at the tail
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The product was introduced to a height of 5 cm into a glass bottle (generator) with a sintered glass disk (pore-size 90 - 150
pm, diameter 30 mm), and the weight was determined . The generator containing the product was placed in a waterbath maintained at 20°C by a the rmostat, and a stream of 200 l/h compressed air was supplied to a downstream mixing chamber .
- Method of holding animals in test chamber: The mixture of air and test substance was passed through a glass distributor to 6 glass tubes in which 3 male and 3 female animals had been placed .
- Source and rate of air: 200 1/h compressed air
Suitable measures were applied to ensure that the air supply had the same temperature as in the laboratories, so that the temperature
in the exposure apparatus was between 19 and 25°C .
There were no deviations from these set conditions which might have adversely affected the results of the study .
After 30 minutes, the generator was replaced by a new one containing fresh test substance as described above . This generator was then used for the remainder of the test .
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The amount of test substance used was determined by reweighing the generators . The nominal concentration was calculated from the amount of test substance consumed and the air volume .
- Duration of exposure:
- 7 h
- Concentrations:
- 3 .8 mg/l (calculated) .
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Clinical examinations took place each workday . Lethality was checked each day
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.8 mg/L air (nominal)
- Exp. duration:
- 7 h
- Remarks on result:
- other: vapour
- Mortality:
- All animals survived.
- Clinical signs:
- other: During exposure: Clinical signs and findings which were observed during exposure are presented in the following table. After exposure and during observation period: No abnormalities were detected in the animals
- Gross pathology:
- No pathologic findings were noted.
Any other information on results incl. tables
Time after beginning of exposure | 1 min | 15 min | 30 min | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h | 7 h |
accelarated respiration | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
eyelid closure | 6 | |||||||||
attempts to escapte | 6 |
The numbers indicate, how many female and male animals showed these clinical signs and findings
.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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