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EC number: 212-052-3 | CAS number: 756-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study (similar to guideline)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Evaluation of acute toxicity after 4-hour exposure to test substance aerosol
- GLP compliance:
- no
- Remarks:
- well documented study
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl methylphosphonate
- EC Number:
- 212-052-3
- EC Name:
- Dimethyl methylphosphonate
- Cas Number:
- 756-79-6
- Molecular formula:
- C3H9O3P
- IUPAC Name:
- dimethyl methylphosphonate
- Details on test material:
- - Name of test material (as cited in study report): Fat 80021/B
No additional data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised on the premises of the testing facility were used for the experiments
- Age at study initiation: no data
- Weight at study initiation: 170 to 205 grams
- Fasting period: animals were fasted overnight before treatment
- Housing: males and females were segregated and kept in Macrolon cages, type 4, (10 animals to a cage)
- Diet (e.g. ad libitum): standard diet of pellets - No. 890, Nafag Gossau SG
- Water (e.g. ad libitum): drinking water
- Acclimation period: a minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±1°C
- Humidity (%): 55±5%
- Photoperiod (hrs dark / hrs light): 10 hours light cycle day
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- head only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Method of holding animals in test chamber: for inhalation the rats were kept on separate PVC tubes positioned radially around the exposure chamber such that snout and nostrils of the animals only were exposed to the aerosol
- Source and rate of air: an air stream was discharged into the exposure chamber through a spray nozzle under a pressure of 2 atm. at a rate of 10 l/min.
- System of generating particulates/aerosols: the aerosol was generated by injecting the test material at a rate of 30 and 60 ml/hour into an air stream
- Method of particle size determination: The size distribution of the aerosol particles was measured with a Cascade Impactor with selectron filters of 25 mm diameter and with a pore size of 0.2 µm (Schleicher and Schuell) at an air flow rate of 17.5 l/min. Fig. 1 contains data on the particle size of the test material.
TEST ATMOSPHERE
The concentration and the particle size distribution of the aerosol in the vicinity of the animals were monitored at 1 hour intervals throughout the aerosol exposure. The concentration was determined gravimetrically by sampling the test atmosphere through a selectron filter of 50 mm diameter and with a pore size of 0.2 µm (Schleicher and Schuell, Feldbach, Switzerland) at an air flow rate of 10 l/min.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: for the 1355 mg/m3 test group, 45% of generated particles were approximately greater than 7 µm, 19.5% ranged between 3 and 7 µm, 30% ranged between 1 and 3 µm and 7% were less than 1 µm in diameter. For the 2589 mg/m3 test group, 51% of generated particles were approximately greater than 7 µm, 28% ranged between 3 and 7 µm, 4% ranged between 1 and 3 µm and 18% were less than 1 µm in diameter.
No additional data - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- average aerosol concentratio were determined gravimetrically
- Duration of exposure:
- 4 h
- Remarks on duration:
- The exposure was started 15 minutes after onset of the aerosol production, when the aerosol had reached an even dispersal throughout the chamber. After a 4 hour inhalation the rats were returned to their cages.
- Concentrations:
- 1355 ± 107 and 2589 ± 176 mg/m3 (no higher concentrations were possible)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Physical condition and incidence of death were monitored throughout an observation period. The animals were submitted at random to a necropsy at the end of the observation period. - Statistics:
- none necessary
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 589 mg/m³ air
- Exp. duration:
- 4 h
- Remarks on result:
- other: no deaths observed up to this dose level
- Mortality:
- No deaths were observed in both test groups until the end of observation period.
- Clinical signs:
- other: After the 4-hour exposure period the rats in both concentrations showed convulsions, exophthalmus, lateral or ventral position and ruffled fur. These symptoms became more accentuated as the concentration was increased. The animals recovered within 6 to 7
- Body weight:
- No data
- Gross pathology:
- Hemorrhages in the lungs and congested organs were observed.
- Other findings:
- None reported
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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