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Diss Factsheets
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EC number: 212-052-3 | CAS number: 756-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study (similar to guideline)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of acute toxicity (LD50) after acute oral application of the test substance to rats
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl methylphosphonate
- EC Number:
- 212-052-3
- EC Name:
- Dimethyl methylphosphonate
- Cas Number:
- 756-79-6
- Molecular formula:
- C3H9O3P
- IUPAC Name:
- dimethyl methylphosphonate
- Details on test material:
- - Name of test material (as cited in study report): 80 021/B
No additional data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised on the premises of the testing facility were used for the experiments
- Age at study initiation: no data
- Weight at study initiation: 105 to 235 grams
- Fasting period: animals were fasted overnight before treatment
- Housing: during the treatment and observation period the animals were housed in groups of 5 in Macrolon cages- (type 3)
- Diet (e.g. ad libitum): standard diet of pellets - No. 890, Nafag Gossau SG
- Water (e.g. ad libitum): drinking water
- Acclimation period: a minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±1°C
- Humidity (%): 55±5%
- Photoperiod (hrs dark / hrs light): 14 hours light cycle day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test substance was administered undiluted
- Doses:
- 1000, 3000, 4500, 6000, 8000, 10000 and 15000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
Physical condition and rate of death were monitored throughout the whole observation period. - Statistics:
- LD50 including 9 5% confidence limits were calculated by the probit analysis method (Goulden A., Methods of Statistical Analysis, John Wiley and Sons, 1960, 3rd printing, pages 404-408)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 10 190 mg/kg bw
- 95% CL:
- 9 140 - 11 360
- Remarks on result:
- other: Deaths were observed in the 8000, 10000 and 15000 mg/kg dose groups
- Mortality:
- One animal (1 female) died in 8000 mg/kg dose group (within 1 day), 5 (1 male and 4 females) in the 10000 mg/kg dose group (within 1-8 days) and all animals of the highest dose group (15000 mg/kg bw).
- Clinical signs:
- other: - In the 1000, 3000 and 4500 mg/kg bw group: lasting >6 hours, reduction in spontaneous motility, ataxia, muscular hypotonia, ventricumbency, hypoventilation; dyspnoea was additionally observed in the 3000 mg/kg dose group and diarrhea in the 4500 mg/kg d
- Gross pathology:
- No data
Any other information on results incl. tables
Table 1: Mortality and body weight during the course of the experiment
Dose (mg/kg bw) |
Morality and percentage of deaths |
Body weight (g) |
|||
Absolute mortality / total tested animals |
Percentage (%) |
Pretest |
On day 15 of test |
||
Males |
Females |
||||
1000 |
0/5 |
0/5 |
0 |
110 |
197 |
3000 |
0/5 |
0/5 |
0 |
135 |
220 |
4500 |
0/5 |
0/5 |
0 |
120 |
191 |
6000 |
0/5 |
0/5 |
0 |
110 |
186 |
8000 |
0/5 |
1/5 |
10 |
120 |
189 |
10000 |
1/5 |
4/5 |
50 |
110 |
195 |
15000 |
5/5 |
5/5 |
100 |
105 |
180 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.