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Diss Factsheets
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EC number: 202-969-7 | CAS number: 101-72-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication does not give sufficient experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylendiamine (IPPD)
- Author:
- Scansetti, G. et al.
- Year:
- 1 987
- Bibliographic source:
- Int. Arch. Occup. Environ. Health 59, 537-543
Materials and methods
- Principles of method if other than guideline:
- other: biomonitoring study
Test material
- Reference substance name:
- N-isopropyl-N'-phenyl-p-phenylenediamine
- EC Number:
- 202-969-7
- EC Name:
- N-isopropyl-N'-phenyl-p-phenylenediamine
- Cas Number:
- 101-72-4
- Molecular formula:
- C15H18N2
- IUPAC Name:
- N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine
- Details on test material:
- IPPD
Constituent 1
Test animals
- Species:
- human
Results and discussion
Main ADME results
- Type:
- other: biomonitoring data
- Results:
- IPPD was detected in exposed workers, a fast and a low excretion rate is suggested
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- IPPD was detected in exposed workers, a fast and a low excretion rate is suggested
Any other information on results incl. tables
Increase of IPPD urinary excretion during the working day was rapid; IPPD concentrations in the urine were always significantly higher in the end- than in the before-shift sample (mean 83.57 vs. 19.55 µg/l; P<0.001, two-tailed; Wilcoxon matched pairs signed-ranks test).
During the week some accumulation occured as before-shift values were higher at the end of the working week than at the beginning, the differences between paired values on monday and on friday is significant (mean 10.8 vs. 25.8 µg/l, p<0.005 two-tailed).
A fast and a slower component of IPPD excetion kinetics is suggested; the slower component of IPPD excretion kinetics appeared from the comparision between end-shift values and before-shift values on the next working day (mean 87.16 vs. 21.92 µg/l, p<0.001 two-tailed); the differences was highly significant, indicating rapid elimination in the hours following exposure; the same is suggested comparing the end-shift values on friday and before-shift values on the following monday (mean 76.21 vs. 10.92 µg/l, p<0.001, two tailed).
Applicant's summary and conclusion
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